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首页> 外文期刊>Life sciences >Development of catecholaminergic neurons in the human medulla oblongata.
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Development of catecholaminergic neurons in the human medulla oblongata.

机译：人的延髓中儿茶酚胺能神经元的发育。

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Distribution and maturation of catecholaminergic (CA) neurons have been studied by tyrosine hydroxylase immunohistochemistry in the medulla oblongata of human fetuses aged 14.5-25 weeks of gestation. Already at 14.5 weeks, CA neurons were observed in two longitudinally oriented cell clusters, one located ventrolaterally in the area of the lateral reticular and ambiguous nuclei, the other one dorsomedially forming 4 groups related to the dorsal vagal nucleus, the commissural nucleus of the vagus, the nucleus of the tractus solitarius and the area postrema. CA neurons in the area postrema were often found close to blood vessels. Scattered intermediate CA neurons were seen between these two larger clusters. CA neurons still appeared immature exhibiting bipolar morphology with only one or two short stout processes, which hardly branched. At 21 weeks, CA neurons occupied essentially the same location, but had a more mature morphology. Though still bipolar in shape, they had thinner and much longer processeswhich frequently branched. Both in the ventrolateral and the dorsomedial cell clusters, these processes were frequently lying close to blood vessels. At 25 weeks, CA cells had matured into multipolar neurons with long thin processes forming fine fiber networks in the ventrolateral medulla as well as around and within the dorsal vagal and solitarius nuclei. Only at this stage, a distinct CA fiber tract was seen located in the region of the tractus solitarius. Our results indicate that CA neurons in the human medulla, which are presumably involved in the control of ventilation and blood pressure, though generated rather early during development, mature relatively late.
机译：酪氨酸羟化酶免疫组织化学研究了儿茶酚胺能（CA）神经元在妊娠14.5-25周的延髓中的分布和成熟。大约在14.5周时，在两个纵向定向的细胞簇中观察到了CA神经元，其中一个位于腹侧，位于外侧网状和歧义核的区域，另一个则背侧形成4个与背迷走神经核（迷走神经连合核）相关的组，孤骨的核和后区域。通常在靠近血管的区域发现视网膜后区域的CA神经元。在这两个较大的簇之间可以看到散布的中间CA神经元。 CA神经元仍显得不成熟，表现出双极形态，只有一个或两个短粗壮的过程，几乎没有分支。在21周时，CA神经元基本上占据了相同的位置，但形态更为成熟。尽管它们的形状仍然是双极的，但它们具有更薄，更长的过程，并且经常分支。在腹侧和背侧细胞簇中，这些过程通常都靠近血管。在第25周时，CA细胞已成熟为多极神经元，具有长而薄的过程，在腹外侧延髓以及背迷走神经和孤窝核周围和内部形成了精细的纤维网络。仅在此阶段，才在独眼道区域内看到一个明显的CA纤维束。我们的结果表明，人的髓质中的CA神经元可能参与了通气和血压的控制，尽管在发育过程中产生得较早，但相对较晚才成熟。

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