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首页> 外文期刊>Cell and Tissue Research >Comparison of the osteogenic potentials of autologous cultured osteoblasts and mesenchymal stem cells loaded onto allogeneic cancellous bone granules
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Comparison of the osteogenic potentials of autologous cultured osteoblasts and mesenchymal stem cells loaded onto allogeneic cancellous bone granules

机译：自体培养成骨细胞和间充质干细胞加载同种异体松质骨颗粒的成骨潜能比较

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摘要

We compared the bone regeneration potentials of autologous cultured osteoblasts and of bone-marrow-derived autologous MSCs in combination with allogeneic cancellous bone granules in a rabbit radial defect model. Radial shaft defects over 15 mm were made in 26 New Zealand white rabbits. The animals underwent insertion of allogeneic cancellous bone granules containing autologous osteoblasts into right-side defects (the experimental group) and of allogeneic cancellous bone granules with autologous MSCs into left-side defects (the control group). To quantitatively assess bone regeneration, radiographic evaluations as well as BMD and BMC measurements were performed 3, 6, 9 and 12 weeks post-implantation and histology as well as micro-CT image analysis were performed at 6 and 12 weeks. Radiographic evaluations 3 weeks post-implantation showed that the experimental group had a higher mean bone quantity index (p<0.05) and micro-CT image analysis showed that experimental sides had a greater mean total regenerated bone volume and surface area than the control sides (p<0.05). Histologic evaluations obtained at 6 and 12 weeks revealed distinctly greater granule resorption and new bone formation in the experimental group. This in vivo study demonstrates that a combination of autologous osteoblasts and small-sized, allogeneic cancellous bone granules leads to more rapid bone regeneration than autologous MSCs and small-sized, allogeneic cancellous bone granules.
机译：我们在兔radial骨缺损模型中比较了自体培养成骨细胞和源自骨髓的自体MSC与同种异体松质骨颗粒结合后的骨再生潜力。在26只新西兰白兔中制造了超过15mm的轴缺陷。将含有自体成骨细胞的同种异体松质骨颗粒插入右侧缺损处（实验组），并将具有自体MSC的同种异体松质骨颗粒插入左侧缺损处（对照组）。为了定量评估骨再生，在植入后3、6、9和12周进行了放射学评估以及BMD和BMC测量，并在6和12周进行了组织学以及显微CT图像分析。植入后3周的影像学评估显示，实验组的平均骨量指数较高（p <0.05），显微CT图像分析显示，实验侧的平均总再生骨量和表面积均比对照组大（ p ＜0.05）。在第6周和第12周进行的组织学评估显示，实验组的颗粒吸收明显增加，并且新骨形成。这项体内研究表明，自体成骨细胞和小尺寸异体松质骨颗粒的组合比自体MSC和小尺寸异体松质骨颗粒的结合能更快地促进骨骼再生。

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