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首页> 外文期刊>Life sciences >The effects of magnesium sulfate on blood-brain barrier disruption caused by intracarotid injection of hyperosmolar mannitol in rats.
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The effects of magnesium sulfate on blood-brain barrier disruption caused by intracarotid injection of hyperosmolar mannitol in rats.

机译：硫酸镁对高渗性甘露醇颈动脉内注射引起的血脑屏障破坏的影响。

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The study was performed to evaluate whether magnesium sulfate could alter the degree of disruption of the blood-brain barrier (BBB) caused by hyperosmotic mannitol. Wistar adult female rats were infused with 25% mannitol into the left internal carotid artery. Each animal received intraperitoneally a 300 mg/kg loading dose of magnesium sulfate, dissolved in 0.9% saline, followed by a further 100 mg/kg dose. In the other group, intracarotid infusion of magnesium sulfate was performed at a dose of 150 mg/kg 10 min before mannitol administration. Evans blue (EB) dye was used as a marker of BBB disruption. The measured serum glucose and magnesium levels increased after mannitol and/or magnesium administration when compared with their initial values before treatment (P < 0.01). Water content of the left hemisphere was significantly increased by hyperosmotic mannitol (P < 0.01). The increased water content in the mannitol-perfused hemisphere was significantly decreased by magnesium treatment (P < 0.05). The content of EB dye in the mannitol-perfused hemisphere markedly increased when compared with the right hemisphere of the same brain (P < 0.01). The EB dye content in the mannitol-perfused hemisphere following both intraperitoneal and intraarterial administration of magnesium decreased when compared with mannitol alone (P < 0.01). We conclude that although magnesium sulfate administration by both intracarotid arterial and intraperitoneal routes attenuates BBB disruption caused by hyperosmolar mannitol, particularly intraperitoneal route of magnesium sulfate administration may provide a useful strategy to limit the transient osmotic opening of the BBB.
机译：进行该研究以评估硫酸镁是否可以改变高渗甘露醇引起的血脑屏障（BBB）破坏程度。 Wistar成年雌性大鼠向左颈内动脉注入25％甘露醇。每只动物腹膜内接受300mg / kg负荷剂量的硫酸镁，溶于0.9％盐水中，然后再给予100mg / kg剂量。在另一组中，在甘露醇给药前10分钟以150 mg / kg的剂量进行颈动脉内硫酸镁的输注。伊文思蓝（EB）染料用作BBB破坏的标志物。与治疗前的初始值相比，甘露醇和/或镁给药后测得的血清葡萄糖和镁水平增加（P <0.01）。高渗甘露醇可显着增加左半球的水分含量（P <0.01）。镁处理显着降低了灌满甘露醇的半球中水的含量（P <0.05）。与同一大脑的右半球相比，灌注甘露醇的半球中EB染料的含量显着增加（P <0.01）。与单独使用甘露醇相比，腹膜内和动脉内施用镁后，在灌满甘露醇的半球中EB染料的含量降低了（P <0.01）。我们得出结论，尽管同时通过颈动脉和腹膜内途径施用硫酸镁可减轻高渗性甘露醇引起的血脑屏障破坏，但尤其是腹膜内施用硫酸镁可为限制血脑屏障的瞬时渗透开放提供一种有用的策略。

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