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Effect of Eugenia dambolana seed kernel on antioxidant defense system in streptozotocin-induced diabetes in rats

机译：丹参种子仁对链脲佐菌素诱导的糖尿病大鼠抗氧化防御系统的影响

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Increased oxidative stress has been suggested to be involved in the pathogenesis and progression of diabetic tissue damage. The aim of this study was to investigate the effect of ethanolic extract of Eugenia jambolana seed kernel on antioxidant defense systems of plasma and pancreas in streptozotocin-induced diabetes in rats. The levels of glucose, vitamin-C, vitamin-E, ceruloplasmin, reduced glutathione and lipidperoxides were estimated in plasma of control and experimental groups of rats. The levels of lipidperoxides, reduced glutathione and activities of superoxide dismutase, catalase and glutathione peroxidase were assayed in pancreatic tissue of control and experimental groups of rats. A significant increase in the levels of plasma glucose, vitamin-E, ceruloplasmin, lipid peroxides and a concomitant decrease in the levels of vitamin-C, reduced glutathione were observed in diabetic rats. The activities of pancreatic antioxidant enzymes were altered in diabetic rats. These alterations were reverted back to near normal level after the treatment with Eugenia jambolana seed kernel and glibenclamide. Histopathological studies also revealed that the protective effect of Eugenia jambolana seed kernel on pancreatic beta-cells. The present study shows that Eugenia jambolana seed kernel decreased oxidative stress in diabetic rats, which intum may be due to its hypoglycemic property. (C) 2004 Elsevier Inc. All rights reserved.
机译：已经提出增加的氧化应激与糖尿病组织损伤的发病机理和进展有关。这项研究的目的是研究链球菌诱导的糖尿病大鼠中番木瓜籽仁乙醇提取物对血浆和胰腺抗氧化防御系统的影响。在对照组和实验组的血浆中估计了葡萄糖，维生素C，维生素E，铜蓝蛋白，还原型谷胱甘肽和脂质过氧化物的水平。在对照组和实验组的胰腺组织中测定脂质过氧化物，还原型谷胱甘肽的水平以及超氧化物歧化酶，过氧化氢酶和谷胱甘肽过氧化物酶的活性。在糖尿病大鼠中，血浆葡萄糖，维生素E，铜蓝蛋白，脂质过氧化物的水平显着增加，维生素C的水平随之下降，谷胱甘肽减少。糖尿病大鼠胰腺抗氧化酶的活性发生改变。在用Eugenia jambolana种子仁和格列本脲处理后，这些改变又恢复到接近正常水平。组织病理学研究还显示，Eugenia jambolana种子仁对胰腺β细胞具有保护作用。本研究表明，Eugenia jambolana种子仁降低了糖尿病大鼠的氧化应激，这可能归因于其降血糖特性。 （C）2004 Elsevier Inc.保留所有权利。

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