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首页> 外文期刊>Life sciences >Orally administrated rare earth element cerium induces metallothionein synthesis and increases glutathione in the mouse liver.
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Orally administrated rare earth element cerium induces metallothionein synthesis and increases glutathione in the mouse liver.

机译：口服稀土元素铈可诱导金属硫蛋白合成，并增加小鼠肝脏中的谷胱甘肽。

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摘要

The influence of oral administration of rare earth element cerium (Ce) was studied in relation to metallothionein (MT) and glutathione (GSH) content in the organs of ICR mice, which were administered heavy metal cadmium (Cd) for comparison. Male ICR mice were divided into 9 groups: 1 control group, 4 cerium groups and 4 cadmium groups, each with 4 mice, for a total of 36 mice. Ce groups included a 20 ppm CeCl(3) diet (Ce-low) group and a 200 ppm CeCl(3) diet (Ce-high) group, as did Cd groups, i.e., a 20 ppm CdCl(2) diet (Cd-low) group and a 200 ppm CdCl(2) diet (Cd-high) group. Each group was subdivided in 2 groups except a control group: 6-week administration group and 12-week administration group. The level of plasma aspartate aminotransferase(AST) activity, plasma alanine aminotransferase(ALT) activity, plasma cholesterol and plasma triglyceride in the Ce-low, Cd-low, Ce-high, and Cd-high group were higher than that of control group, although there were no significant differences (p > 0.05). By contrast, both Ce and Cd groups had higher levels of MT and GSH in hepatic cells compared to the control group (p < 0.05) and decreased liver tissue level of lipoperoxide (p < 0.05). These groups also had decreased plasma superoxide dismutase (SOD) activity (p < 0.05), and increased plasma level of lipoperoxide (p > 0.05). In conclusion, it is suggested that orally administered Ce increases MT and GSH as an antioxidant in the mouse liver, and these reaction are probably caused by increases in the oxidative stress with Ce.
机译：研究了ICR小鼠器官中金属硫蛋白（MT）和谷胱甘肽（GSH）含量与稀土元素铈（Ce）口服的影响，ICR小鼠经重金属镉（Cd）进行比较。将雄性ICR小鼠分为9组：1个对照组，4个铈组和4个镉组，每组4只小鼠，总共36只小鼠。 Ce组包括20 ppm CeCl（3）饮食（低Ce）组和200 ppm CeCl（3）饮食（Ce高）组，而Cd组也是如此，即20 ppm CdCl（2）饮食（Cd -低）组和200 ppm CdCl（2）饮食（高Cd）组。除对照组外，每组又分为2组：6周给药组和12周给药组。 Ce-low，Cd-low，Ce-high和Cd-high组的血浆天门冬氨酸氨基转移酶（AST）活性，血浆丙氨酸氨基转移酶（ALT）活性，血浆胆固醇和血浆甘油三酸酯水平高于对照组，尽管没有显着差异（p> 0.05）。相比之下，Ce和Cd组的肝细胞MT和GSH含量均高于对照组（p <0.05），肝组织中的过氧化脂质水平降低（p <0.05）。这些组的血浆超氧化物歧化酶（SOD）活性也降低（p <0.05），脂过氧化物的血浆水平升高（p> 0.05）。总之，建议口服Ce可增加小鼠肝脏中MT和GSH作为抗氧化剂的含量，这些反应可能是由于Ce的氧化应激增加引起的。

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