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首页> 外文期刊>Life sciences >Insulin sensitizing and alpha-glucoamylase inhibitory action of sennosides, rheins and rhaponticin in Rhei Rhizoma.
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Insulin sensitizing and alpha-glucoamylase inhibitory action of sennosides, rheins and rhaponticin in Rhei Rhizoma.

机译：大黄根茎中皂苷，大黄酸和大黄素的胰岛素增敏和α-葡糖淀粉酶抑制作用。

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摘要

Extracts from Rhei Rhizoma extracts (RR) have been reported to attenuate metabolic disorders such as diabetic nephropathy, hypercholesterolemia and platelet aggregation. With this study we investigated the anti-diabetic action of 70% ethanol RR extract in streptozotocin-induced diabetic mice, and determined the action mechanism of active compounds of RR in vitro. In the diabetic mice, serum glucose levels at fasting and post-prandial states and glucose area under the curve at modified oral glucose tolerance tests were lowered without altering serum insulin levels, indicating that RR contained potential anti-diabetic agents. The fractions fractionated from RR extracts by XAD-4 column revealed that 60%, 80% and 100% methanol fractions enhanced insulin sensitivity and inhibited alpha-glucoamylase activity. The major compounds of these fractions were sennosides, rhein and rhaponticin. Rhaponticin and rhein enhanced insulin-stimulated glucose uptake in 3T3-L1 adipocytes. Rhaponticin increased adipocytes with a differentiating effect similar to pioglitazone, but rhein and sennoside B decreased triglyceride accumulation. Sennoside A and B inhibited alpha-glucoamylase activity as much as acarbose. In conclusion, a crude extract of RR improves glucose intolerance by enhancing insulin-stimulated glucose uptake and decreasing carbohydrate digestion via inhibiting alpha-glucoamylase activity. Rhein and rhaponticin are potential candidates for hypoglycemic agents.
机译：据报道，大黄提取物（RR）的提取物可减轻代谢性疾病，如糖尿病性肾病，高胆固醇血症和血小板聚集。通过这项研究，我们研究了70％乙醇RR提取物在链脲佐菌素诱导的糖尿病小鼠中的抗糖尿病作用，并确定了RR活性化合物在体外的作用机理。在糖尿病小鼠中，在不改变血清胰岛素水平的情况下，降低了空腹和餐后状态下的血清葡萄糖水平，以及经修改的口服葡萄糖耐量试验的曲线下的葡萄糖面积，这表明RR含有潜在的抗糖尿病药。通过XAD-4色谱柱从RR提取物中分离得到的馏分表明，60％，80％和100％的甲醇馏分增强了胰岛素敏感性，并抑制了α-葡糖淀粉酶的活性。这些级分的主要化合物是番石榴苷，大黄酸和大黄素。 Rhaponticin和rhein增强了3T3-L1脂肪细胞中胰岛素刺激的葡萄糖摄取。 Rhaponticin增加脂肪细胞的分化作用与吡格列酮相似，但大黄酸和sennoside B减少甘油三酸酯的积累。番泻苷A和B与阿卡波糖一样抑制α-葡糖淀粉酶的活性。总之，RR的粗提物可通过增强胰岛素刺激的葡萄糖摄取并通过抑制α-葡糖淀粉酶活性来减少碳水化合物的消化，从而改善葡萄糖耐量。大黄酸和大黄素是降血糖药的潜在候选药物。

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