• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >Effects of renovascular hypertension on reproductive function in male rats.
【24h】

Effects of renovascular hypertension on reproductive function in male rats.

机译：肾性高血压对雄性大鼠生殖功能的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: The present study investigated the effects of renovascular hypertension (2K/1C model) on the reproductive function of male rats, represented by sexual behavior, plasma prolactin (PRL), luteinizing hormone (LH), follicle-stimulating hormone (FSH) and testosterone, and spermatogenesis. METHODS: The present experiments were performed to investigate the reproductive function of 2K/1C male Wistar rats and compare with 2K/1C male rats successfully treated for hypertension with nifedipine and was divided in the following groups: (1) Sham+V (n=10): Sham-operated males with vehicle used; (2) Sham+N (n=13): Sham-operated males treated with nifedipine (10 mg/kg/day); (3) 2K/1C+V (n=14): 2K/1C-operated males with vehicle used; and (4) 2K/1C+N (n=16): 2K/1C-operated males treated with nifedipine. RESULTS: The data indicated an association between hypertension induced by the 2K/1C model and reduction of reproductive function, as demonstrated by an impairment of sexual behavior, higher plasma PRL and lowerplasma testosterone and FSH. The treatment with nifedipine prevented the reduction of sexual behavior and the increase of plasma PRL, but did not alter the reduction of plasma testosterone and FSH and spermatogenesis of 2K/1C rats. CONCLUSIONS: Reproductive function is adversely affected in the 2K/1C animal model, and high blood pressure plays a role in the modulation of plasma PRL and sexual behavior. Moreover, other events, without high blood pressure, but with high plasma renin activity associated with the 2K/1C model, contribute directly to the reduction of plasma testosterone and FSH and impaired spermatogenesis.
机译：目的：本研究以性行为，血浆催乳素（PRL），促黄体激素（LH），促卵泡激素（FSH）和雌性激素为代表，研究肾血管性高血压（2K / 1C模型）对雄性大鼠生殖功能的影响。睾丸激素和生精。方法：本实验旨在研究2K / 1C雄性Wistar大鼠的生殖功能，并与硝苯地平成功治疗高血压的2K / 1C雄性大鼠进行比较，分为以下两组：（1）Sham + V（n = 10）：假装男性，使用车辆; （2）Sham + N（n = 13）：用硝苯地平治疗的假手术男性（10 mg / kg /天）; （3）2K / 1C + V（n = 14）：使用2K / 1C的男性使用了车辆; （4）2K / 1C + N（n = 16）：用硝苯地平治疗的2K / 1C手术男性。结果：数据表明，由2K / 1C模型诱发的高血压与生殖功能下降之间存在关联，这表现为性行为受损，血浆PRL升高，血浆血浆睾丸激素和FSH升高。硝苯地平治疗可以防止性行为的减少和血浆PRL的增加，但不会改变2K / 1C大鼠血浆睾丸激素和FSH的减少以及精子生成。结论：在2K / 1C动物模型中，生殖功能受到不利影响，并且高血压在血浆PRL和性行为的调节中起作用。此外，其他事件，没有高血压，但具有与2K / 1C模型相关的高血浆肾素活性，直接导致血浆睾丸激素和FSH减少以及精子发生受损。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号