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首页> 外文期刊>Reproductive toxicology >Effects of methylmercury on male reproductive functions in Wistar rats.
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Effects of methylmercury on male reproductive functions in Wistar rats.

机译：甲基汞对Wistar大鼠雄性生殖功能的影响。

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In this study we investigated the effects of subacute exposure to methylmercury (MeHg) on male reproductive functions in rats by means of determination of alterations in structural and functional parameters. Adult male Wistar rats received 0, 0.5, 1.0 or 3.0 mg/kg/body weight/day orally, daily MeHg for 14 days. Sperm motility, the relative sperm count and transit time in the caput/corpus epididymis, were all reduced at all doses. The lowest dose increased the number of sperm head abnormalities; daily sperm production was elevated at the intermediate dose; while at the highest dose there was a decrease in serum testosterone levels and a rise in mercury (Hg) content in reproductive organs, liver and kidneys. In conclusion, MeHg exposure produced damages on male reproductive functions which may be attributed, at least in part, to the reduction in serum testosterone levels. These consequences could potentially result in infertility in rats.
机译：在这项研究中，我们通过确定结构和功能参数的变化，调查了亚急性暴露于甲基汞（MeHg）对大鼠雄性生殖功能的影响。成年雄性Wistar大鼠口服，每天MeHg口服0、0.5、1.0或3.0 mg / kg /体重/天，共14天。在所有剂量下，精子活力，相对精子数量和附睾/附睾附体的通过时间均减少。最低剂量增加了精子头异常的数量;在中等剂量下，每日精子产量增加;在最高剂量下，生殖器官，肝脏和肾脏中的血清睾丸激素水平下降，汞（Hg）含量上升。总之，甲基汞的暴露会对男性生殖功能造成损害，这至少可以部分归因于血清睾丸激素水平的降低。这些后果可能导致大鼠不育。

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