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首页> 外文期刊>Life sciences >Ontogeny of renal renin in congenital hypothyroid rats.
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Ontogeny of renal renin in congenital hypothyroid rats.

机译：先天性甲状腺功能减退大鼠肾脏肾素的个体发育。

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摘要

In the present study we have found age-related differences between the renal renin activity (RRA) and the immunoreactive renal renin (IRR) profiles during the neonatal development of the rat. RRA was markedly greater in newborn rats than in adult ones, while IRR was low at birth and progressively increased until adulthood. These observations suggest the existence of a control mechanism operating either at the level of the translation of the template or at a post-translational level which varies throughout the development. Since thyroid hormones have been demonstrated to affect several renin-angiotensin components, the neonatal RRA and IRR profiles in congenital hypothyroid rats were evaluated to determine whether renal renin activity or its synthesis could be endogenously regulated by thyroid hormones in the early stages of life. Although significant differences were observed in the RRA profiles of congenital hypothyroid and control rats, no changes were found in the relative amount of immunoreactive protein. These findings indicate that thyroid hormone deficiency does not directly affect renal renin expression during the critical period of the normal morpho-functional development of the newborn.
机译：在本研究中，我们发现在大鼠的新生儿发育过程中，肾素活性（RRA）和免疫反应性肾素（IRR）谱之间存在年龄相关的差异。新生大鼠的RRA明显大于成年大鼠，而IRR在出生时很低，直到成年后才逐渐升高。这些观察结果表明存在控制机制，该控制机制在模板的翻译水平上或在翻译后水平上运行，该机制在整个开发过程中都不同。由于已证明甲状腺激素会影响几种肾素-血管紧张素成分，因此对先天性甲状腺功能低下大鼠的新生儿RRA和IRR谱进行了评估，以确定在生命的早期阶段是否可以通过甲状腺激素内源性调节肾素活性或其合成。尽管先天性甲状腺功能减退和对照组大鼠的RRA谱存在显着差异，但免疫反应蛋白的相对含量未见变化。这些发现表明，在新生儿正常形态功能发育的关键时期，甲状腺激素缺乏症不会直接影响肾素的表达。

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