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Central gastrin inhibits feeding behavior and food passage in neonatal chicks.

机译:中央胃泌素抑制新生雏鸡的进食行为和食物通过。

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The gastrin/cholecystokinin (CCK) family is recognized as the principal family of hormones involved in regulation of the gastrointestinal tract CCK is recognized as a satiety hormone in mammalian species, but it has been suggested that gastrin rather CCK may have an important role in controlling feeding behavior in the neonatal chick through a poorly developed blood brain barrier. So far, however, there is no direct evidence that central gastrin inhibits food intake in neonatal chicks. The aim of this study was to elucidate whether central administration of gastrin 1) inhibits feeding behavior and 2) alters food passage from the crop. The effects of central administration of gastrin on food intake were investigated in experiment 1. Birds (2-day-old) were food-deprived for 3 h and then gastrin or saline was injected intracerebroventricularly. Gastrin strongly inhibited food intake in a dose-dependent fashion for 2 h. Thereafter, the effects of central gastrin on feeding behavior and serum corticosterone concentration were examined in experiment 2. Following central administration of gastrin, food intake was depressed and pecking behavior was inhibited. Serum corticosterone concentration was not altered by central administration of gastrin. The influence of central gastrin on food passage from the crop was investigated in experiment 3. Central administration of gastrin clearly delayed food passage. In conclusion, central gastrin appears to have a strong effect for the satiety and gastrointestinal motility in the neonatal chick.
机译:胃泌素/胆囊收缩素(CCK)家族被认为是参与胃肠道调节的激素的主要家族,在哺乳动物中被认为是饱腹感激素,但是有人认为,胃泌素而不是CCK可能在控制中起重要作用。通过发育不良的血脑屏障对新生雏鸡的摄食行为。然而,到目前为止,尚无直接证据表明中央胃泌素能抑制新生雏鸡的食物摄入。这项研究的目的是阐明胃泌素的集中管理是否1)抑制了进食行为,2)改变了农作物的食物流通。在实验1中研究了胃泌素的集中给药对食物摄入的影响。将2天大的家禽断食3小时,然后脑室内注射胃泌素或盐水。胃泌素以剂量依赖性方式强烈抑制食物摄入2小时。此后,在实验2中检查了中央胃泌素对进食行为和血清皮质酮浓度的影响。在中央给予胃泌素后,食物摄取受到抑制并且啄食行为受到抑制。胃泌素的中央给药不会改变血清皮质激素的浓度。在实验3中研究了中央胃泌素对农作物食物通过的影响。集中施用胃泌素明显延迟了食物通过。总之,中央胃泌素似乎对新生雏鸡的饱腹感和胃肠道蠕动具有很强的作用。

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