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首页> 外文期刊>Life sciences >Effects of the opioid remifentanil on olfactory function in healthy volunteers.
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Effects of the opioid remifentanil on olfactory function in healthy volunteers.

机译：阿片类药物瑞芬太尼对健康志愿者嗅觉功能的影响。

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摘要

The effects of opioids on human subjective olfactory function have rarely been investigated. This is despite the fact that opioid receptors are widely distributed throughout the olfactory systems. Using an established validated test of subjective olfactory function, olfactory threshold, odor discrimination and odor identification performance were tested in 16 healthy volunteers before opioid administration and at steady state after 3 hours remifentanil infusion. Each one man and one women were assigned randomly to one out of eight predefined remifentanil target plasma concentrations: 0, 1.2, 1.8, 2.4, 3, 3.6, 4.8, and 6 ng/ml. In the thirteen subjects that had completed the tests, olfactory thresholds were elevated with increasing remifentanil dose, and this correlated statistically significant with the remifentanil dose. Remifentanil plasma concentrations were linearly related to changes in olfactory thresholds. In contrast, effects of remifentanil on odor discrimination and identification were not statistically significant. However, remifentanil target plasma concentrations were also significantly correlated with the subjects' ratings of tiredness and drowsiness, although only drowsiness was significantly correlated with the differences in odor thresholds. We conclude that opioid administration leads to impaired olfactory function expressed in raised olfactory thresholds. This is compatible with previously reported opioidergic effects at the level of the olfactory bulb.
机译：阿片类药物对人的主观嗅觉功能的影响很少进行研究。尽管存在这样的事实，阿片样物质受体广泛分布在整个嗅觉系统中。使用已建立的经验证的主观嗅觉功能测试，在阿片类药物给药前和瑞芬太尼输注3小时后的稳态下，对16名健康志愿者进行了嗅觉阈值，气味识别和气味识别性能的测试。将每一个男人和一个女人随机分配给八种预定的瑞芬太尼目标血浆浓度中的一种：0、1.2、1.8、2.4、3、3.6、4.8和6 ng / ml。在完成测试的13位受试者中，嗅觉阈值随瑞芬太尼剂量的增加而升高，这与瑞芬太尼剂量在统计学上相关。瑞芬太尼血浆浓度与嗅觉阈值的变化线性相关。相比之下，瑞芬太尼对气味识别和识别的影响在统计学上不显着。然而，瑞芬太尼目标血浆浓度也与受试者的疲倦和嗜睡等级显着相关，尽管只有嗜睡与气味阈值的差异显着相关。我们得出的结论是，阿片类药物的给药导致嗅觉阈值中表达的嗅觉功能受损。这与先前报道的嗅球水平的去皮作用有关。

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