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首页> 外文期刊>Life sciences >Age-related decline of serotonin transporters in living human brain of healthy males.
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Age-related decline of serotonin transporters in living human brain of healthy males.

机译：健康男性的活人脑中血清素转运蛋白的年龄相关下降。

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摘要

There is growing interest in serotonin transporter (5-HTT) function in the human brain, since alteration in 5-HTT has been suggested in a variety of neurophychiatric disorders. Age-related decline in postsynaptic 5-HT receptors has been demonstrated in postmortem human studies and in vivo imaging studies, and has been assumed to be related to changes in mental function in the normal aging process. However, few studies have investigated the aging effect on 5-HTT in human brain in vivo, since the availability of suitable ligands has been limited. To investigate the aging effect on 5-HTT in living human brain, we performed positron emission tomography (PET) scans with a selective ligand for 5-HTT, [11C](+)McN5652. We examined 28 healthy male volunteers aged between 20 and 79 years. The uptake was quantified in the thalamus and midbrain by graphical analysis with the cerebellum as a reference tissue, and binding potential (BP) was used for the index of 5-HTT binding. There was a significant age-related decline in BP in the thalamus and midbrain. The decline in [11C](+)McN5652 binding was 9.6% per decade in the thalamus and 10.5% per decade in the midbrain.
机译：人们已经对5-羟色胺转运蛋白（5-HTT）在人脑中的功能产生了越来越大的兴趣，因为5-HTT的改变已在多种神经系统性疾病中被提出。验尸研究和体内成像研究表明，年龄相关的突触后5-HT受体下降，并被认为与正常衰老过程中精神功能的变化有关。然而，由于合适的配体的可用性受到限制，很少有研究研究体内对人脑中5-HTT的衰老作用。若要研究对人的大脑中5-HTT的衰老影响，我们用5-HTT的选择性配体[11C]（+）McN5652进行了正电子发射断层扫描（PET）扫描。我们检查了28位年龄在20至79岁之间的健康男性志愿者。通过图形分析以小脑为参照组织，定量丘脑和中脑的摄取，结合电位（BP）用于5-HTT结合指数。丘脑和中脑的血压明显与年龄相关。丘脑中[11C]（+）McN5652结合的下降为每十年9.6％，中脑为每十年10.5％。

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