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首页> 外文期刊>Cell and Tissue Research >Insulin-like growth factor I is expressed in classical and nodular lymphocyte-predominant Hodgkin's lymphoma tumour and microenvironmental cells
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Insulin-like growth factor I is expressed in classical and nodular lymphocyte-predominant Hodgkin's lymphoma tumour and microenvironmental cells

机译：胰岛素样生长因子I在经典和结节性淋巴细胞为主的霍奇金淋巴瘤肿瘤和微环境细胞中表达

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Hodgkin's lymphoma (HL) is among the most frequent nodal lymphomas in the Western world and is classified into two disease entities: nodular lymphocyte-predominant Hodgkin's lymphoma (NLPHL) and classical Hodgkin's lymphoma (cHL, 95 % of all HL). HL lesions are characterised by a minority of clonal neoplastic cells, namely Hodgkin and Reed-Sternberg (HRS) cells and their variants in cHL and lymphocyte-predominant (LP) cells in NLPHL, both occurring within a microenvironment of, for example, reactive T and B cells, macrophages and granulocytes that are assumed to support the proliferation and maintenance of neoplastic cells through cytokines, chemokines and growth factors. Insulin-like growth factor I (IGF-I) is an important growth factor involved in proliferation, differentiation, apoptosis and cell survival of numerous (including immune) tissues and probably has a role in tumour pathogenesis and maintenance. Although HL is characterised by disturbed cell differentiation and apoptosis mechanisms, with the involvement of the IGF-I receptor (IGF-1R), the distinct location of IGF-I in HL has not yet been defined. We localise IGF-I by double-immunofluorescence in frequent neoplastic cells of all cHL and NLPHL cases investigated. Additionally, IGF-I immunoreactivity is detected in high endothelial venules and various immune cells within the surrounding tissue of cHL including neutrophils and macrophages. IGF-1R immunoreactivity of variable intensity is found in HRS cells and high endothelial venules within the microenvironment in cHL. We assume that autocrine and paracrine IGF-I plays an anti-apoptotic role in tumour pathogenesis and in shaping the tumour microenvironment.
机译：霍奇金淋巴瘤（HL）是西方世界上最常见的淋巴结淋巴瘤之一，分为两种疾病实体：结节性淋巴细胞为主的霍奇金淋巴瘤（NLPHL）和经典霍奇金淋巴瘤（cHL，占所有HL的95％）。 HL病变的特点是少数克隆性肿瘤细胞，即霍奇金和里德-斯特恩伯格（HRS）细胞及其在cHL中的变体和NLPHL中的淋巴细胞为主（LP）细胞，均发生在例如反应性T的微环境中B细胞，巨噬细胞和粒细胞被认为通过细胞因子，趋化因子和生长因子来支持肿瘤细胞的增殖和维持。胰岛素样生长因子I（IGF-1）是一种重要的生长因子，参与许多（包括免疫）组织的增殖，分化，凋亡和细胞存活，并且可能在肿瘤的发病机理和维持中起作用。尽管HL的特征在于受干扰的细胞分化和凋亡机制，但由于IGF-I受体（IGF-1R）的参与，IGF-1在HL中的独特位置尚未确定。我们通过调查的所有cHL和NLPHL病例的常见赘生性细胞中的双重免疫荧光来定位IGF-I。此外，在高内皮小静脉和cHL周围组织（包括嗜中性粒细胞和巨噬细胞）内的各种免疫细胞中检测到IGF-1免疫反应性。在cHL的微环境中的HRS细胞和高内皮小静脉中发现了不同强度的IGF-1R免疫反应性。我们假设自分泌和旁分泌IGF-I在肿瘤发病机理和塑造肿瘤微环境中起抗凋亡作用。

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