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首页> 外文期刊>Life sciences >Effects of maternal deprivation on adrenal and behavioural responses in rats with anterodorsal thalami nuclei lesions.
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Effects of maternal deprivation on adrenal and behavioural responses in rats with anterodorsal thalami nuclei lesions.

机译：母体剥夺对前角质丘脑核损伤大鼠肾上腺和行为反应的影响。

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There is evidence that repeated maternal isolation of neonatal rats may influence both emotional behavior and Hypothalamic-Pituitary Adrenal (HPA) activity. On the other hand the Anterodorsal Thalami Nuclei (ADTN) exerts an inhibitory influence on the hypophyso-adrenal system under basal and stressful conditions. In the present work we investigated whether neonatal maternal deprivation produces long term effects on the ADTN regulation of behavioral patterns (open field test) and on HPA axis activity. Specifically, we sought to determine whether adult female rats with ADTN lesions, previously isolated for 4.5 hours daily during the first 3 weeks of life, react in endocrinologically and behaviourally distinct manner as compared to controls. The examined groups were: non maternally deprived (NMD)/sham lesioned, NMD/lesioned, maternally deprived (MD)/sham lesioned, MD/lesioned with and without the open field test. At 3 months MD/sham lesioned animals showed a marked decrease in ambulation (P < 0.01), and with ADTN lesion, the rearing values were lower (P < 0.01) and grooming higher (P < 0.05) than NMD. This last data would indicate a high emotional index. Regarding the activity of the HPA axis, maternal deprivation induced a significant decrease in plasma ACTH concentration both in sham and lesioned animals (P < 0.001), and plasma Corticosterone (C) increased in sham animals (P < 0.001). This data would indicate a higher sensitivity of the adrenal glands. After the open field test ACTH and C were different between deprived and non-deprived animals depending on the ADTN lesion. Taking into consideration the increase of ACTH levels in sham lesioned MD animals exposed to the test, we could conclude that this new situation was a stressful situation. Finally in the present work, it was very difficult to relate the behavioral parameters with the endocrine data. It is known that depending on the context, corticosteroids may produce opposite effects on emotional behavior via different receptors in the brain.In summary, neonatal maternal deprivation induced alterations of behavioral patterns and affected the ADTN inhibitory influence on ACTH and C secretion.
机译：有证据表明，反复隔离母体对新生大鼠可能会影响情绪行为和下丘脑-垂体-肾上腺（HPA）活性。另一方面，在基础和压力条件下，前嗅丘脑核（ADTN）会对下垂-肾上腺系统产生抑制作用。在目前的工作中，我们调查了新生儿母体剥夺是否对行为模式的ADTN调节（开放视野试验）和HPA轴活动产生长期影响。具体而言，我们试图确定在出生前三周内每天隔离4.5小时的ADTN损伤成年雌性大鼠是否以内分泌和行为上不同的方式与对照组发生反应。检查的组为：非母体剥夺（NMD）/假病变，NMD /病变，带母体剥夺（MD）/假病变，MD /病变（有或没有露天试验）。在3个月的MD /假手术损伤动物上，其行走能力显着下降（P <0.01），而在ADTN损伤下，其饲养值低于NMD（P <0.01），修饰水平更高（P <0.05）。最后的数据表明情绪指数很高。关于HPA轴的活性，假手术和患病动物的母体剥夺都导致血浆ACTH浓度显着降低（P <0.001），而假手术动物血浆皮质酮（C）升高（P <0.001）。该数据表明肾上腺的敏感性更高。野外试验后，根据ADTN病灶，被剥夺动物和非被剥夺动物的ACTH和C均不同。考虑到暴露于该试验的假病变MD动物中ACTH水平的增加，我们可以得出结论，这种新情况是压力大的情况。最后，在目前的工作中，很难将行为参数与内分泌数据联系起来。众所周知，皮质类固醇激素可能通过不同的大脑受体对情绪行为产生相反的作用。总之，新生儿的母体剥夺会引起行为模式的改变，并影响ADTN对ACTH和C分泌的抑制作用。

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