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首页> 外文会议>International Society for Neuroimmunomodulation >Early Maternal Deprivation in Rats A Proposed Animal Model for the Study ofDevelopmental Neuroimmunoendocrine Interactions
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Early Maternal Deprivation in Rats A Proposed Animal Model for the Study ofDevelopmental Neuroimmunoendocrine Interactions

机译：大鼠早期的孕产妇剥夺了一个拟议的动物模型，用于研究的培养神经内分泌性相互作用

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Adult animals that had been subjected to a single prolonged episode of maternaldeprivation (MD) [24 h, postnatal day (PND) 9-10] show long-term behavioral alter-ations that resemble specific symptoms of schizophrenia. Moreover, at adolescenceMD rats showed depressive-like behavior and altered motor responses. According tothe neurodevelopmental hypothesis, certain behavioral abnormalities observed in MDanimals may be related to altered neurodevelopmental processes triggered by MD-induced elevated glucocorticoids in relevant specific brain regions. We review herethese neuroendocrine effects and show new data indicating that the MD procedure in-duces diverse detrimental effects on the immune system that are already revealed inthe short term (PND 13) and persist into adulthood. These long-lasting effects mightbe related to altered hypothalamus-pituitary-adrenal axis activity and to social as wellas nutrition-related factors. In fact, MD induces long-lasting decreases in body weight.In view of our findings we propose the present MD procedure as a potentially usefulmodel to analyze developmental interactions between early psychophysiological stressand immunodeficient states.
机译：已经经受纯期延长的成年动物（MD）[24小时，后期（PND）9-10]显示了类似精神分裂症的特异性症状的长期行为改变。此外，在Adolescencemd大鼠表现出抑郁的行为和改变的电动机响应。根据神经发育的假设，MDANIMALS中观察到的某些行为异常可能与MD诱导的血糖皮质激素引发的改变的神经发育过程相关的相关特定脑区。我们审查了紫色神经内分泌效应，并展示了新的数据，表明MD程序对免疫系统进行了不同的不利影响，这些免疫系统已经显示出短期（PND 13）并持续到成年期。这些长持久的效果可能与次丘脑 - 垂体 - 肾上腺轴活动改变有关，以及社会作为与井宇营养相关的因素有关。事实上，MD诱导体重减轻的延续减少。在我们的研究结果的视图中，我们提出了本MD程序作为潜在的有用的模型，分析早期心理生理压力和免疫缺陷之间的发育相互作用。

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