The endocannabinoid anandamide affects the synthesis of human syncytiotrophoblast-related proteins

Costa M. A.; Fonseca B. M.; Mendes A.; Braga J.; Teixeira N. A.; da Silva Georgina Correia

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The endocannabinoid anandamide affects the synthesis of human syncytiotrophoblast-related proteins

机译：内源性大麻素anandamide影响人类合体滋养层相关蛋白的合成

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The human syncytiotrophoblast (hST) has a major role in the production of important placental hormones. Several molecules regulate hST endocrine function but the role of endocannabinoids in this process is still unknown. Here, we report that the endocannabinoid anandamide (AEA) decreased cAMP levels, impaired human chorionic gonadotropin secretion, placental alkaline phosphatase activity and decreased aromatase mRNA levels and protein expression, through cannabinoid (CB) receptor activation. AEA also downregulated leptin and placental protein 13 transcription, though via a CB receptor-independent mechanism. All this evidence suggests AEA is a novel modulator of hormone synthesis by the syncytiotrophoblast, supporting the importance of the endocannabinoid signalling in placental function.

机译：人合体滋养层细胞（hST）在重要胎盘激素的产生中起主要作用。几种分子调节hST的内分泌功能，但是内源性大麻素在此过程中的作用仍是未知的。在这里，我们报道了通过大麻素（CB）受体激活，内源性大麻素anandamide（AEA）降低了cAMP水平，受损的绒毛膜促性腺激素分泌，胎盘碱性磷酸酶活性以及芳香化酶mRNA水平和蛋白质表达降低。 AEA还通过CB受体独立机制下调了瘦素和胎盘蛋白13的转录。所有这些证据表明，AEA是合体滋养层细胞激素合成的新型调节剂，支持内源性大麻素信号在胎盘功能中的重要性。

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《Cell and Tissue Research》 |2015年第2期|共6页
作者
Costa M. A.; Fonseca B. M.; Mendes A.; Braga J.; Teixeira N. A.; da Silva Georgina Correia;
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正文语种 eng
中图分类细胞生物学;
关键词
Anandamide; Endocannabinoid signalling; Placental proteins; Human syncytiotrophoblast; Placenta;

机译：Anandamide;内源性大麻素信号;胎盘蛋白;人类合体滋养细胞;胎盘;

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1. The endocannabinoid anandamide affects the synthesis of human syncytiotrophoblast-related proteins [J] . Costa M. A., Fonseca B. M., Mendes A., Cell and Tissue Research . 2015,第2期

机译：内源性大麻素anandamide影响人类合体滋养层相关蛋白的合成
2. Quantification of anandamide and 2-arachidonoylglycerol plasma levels to examine potential influences of tetrahydrocannabinol application on the endocannabinoid system in humans [J] . ThiemeU., SchellingG., HauerD., Drug testing and analysis . 2014,第1a2期

机译：定量Anandamide和2-arachidonoylglycerol血浆水平以检查四氢大麻酚的应用对人体内源性大麻素系统的潜在影响
3. The Endocannabinoid, Anandamide, Acts as a Novel Inhibitor of LPS-Induced Inflammasome Activation in Human Gastric Cancer AGS Cell Line: Involvement of CB1 and TRPV1 Receptors [J] . Sahar Sadat Sedeighzadeh, Hamid Galehdari, Mohammad Reza Tabandeh, Mediators of inflammation . 2021,第a期

机译：Anandandaboid，Anandamide，作为LPS诱导的人胃癌AGS细胞系中LPS诱导的炎症激活的新抑制剂：CB1和TRPV1受体的累积
4. Validated LC/MS/MS Method for the quantitative analysis of the Endocannabinoid Anandamide and Other Ethanolamides in Human Plasma [C] . Joe Palandra, Yanhua Zhang, Jeff Prusakiewicz, ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：验证的LC / MS / MS方法，用于对人血浆中的内胆胆碱和其他乙醇酰胺的定量分析
5. Anandamide analogs as affinity probes for proteins of the endocannabinoid system. [D] . Goutopoulos, Andreas. 2000

机译：Anandamide类似物作为内源性大麻素系统蛋白的亲和探针。
6. Membrane-mediated action of the endocannabinoid anandamide on membrane proteins: implications for understanding the receptor-independent mechanism [O] . Djalma Medeiros, Laíz da Costa Silva-Gonçalves, Annielle Mendes Brito da Silva, -1

机译：内源性大麻素南膜酰胺对膜蛋白的膜介导作用：对理解受体非依赖性机制的启示
7. The endocannabinoid system in human keratinocytes: Evidence that anandamide inhibits epidermal differentiation through CB1 receptor-dependent inhibition of protein kinase C, activating protein-1, and transglutaminase [O] . Maccarrone, M, Di Rienzo, M, Battista, N, 2003

机译：人角质形成细胞中的内源性大麻素系统：Anandamide通过CB1受体依赖性抑制蛋白激酶C，激活蛋白1和转谷氨酰胺酶抑制表皮分化的证据

The endocannabinoid anandamide affects the synthesis of human syncytiotrophoblast-related proteins

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