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首页> 外文期刊>Cell and Tissue Research >Expression of odorant receptor Olfr78 in enteroendocrine cells of the colon
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Expression of odorant receptor Olfr78 in enteroendocrine cells of the colon

机译：嗅觉受体Olfr78在结肠肠内分泌细胞中的表达

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摘要

The precise regulation of digestive and other physiological processes in the gastrointestinal tract in accordance with the food ingested requires continuous monitoring of the luminal content by chemosensory cells. With regard to the detection of chemical compounds in the lumen of the gastrointestinal tract, G-protein-coupled receptors (GPCRs) are interesting signaling proteins, since some of them are well known to bind to macronutrients, including sugars, amino acids and lipids. We report that Olfr78, a member of the odorant receptor (OR) class of GPCRs, is expressed in the murine gut. Our results support the concept that Olfr78 is activated by propionate, an important nutrient generated in the colon by microbiota. In situ hybridization and immunohistochemical approaches show that Olfr78 is expressed in the colon but is absent from other gastrointestinal compartments, such as the stomach and small intestine. In the colon, Olfr78 is expressed by a subset of epithelial cells lining the crypts; these cells are endowed with an apical process protruding towards the crypt lumen. The Olfr78-positive cells in the colon co-express the hormonal peptide YY (PYY), a marker for given enteroendocrine cells. The expression of the propionate receptor Olfr78 in epithelial enteroendocrine cells of the colon suggests that Olfr78 is involved in the regulation of hormone secretion from such cells, as evoked by nutritional compounds.
机译：根据摄入的食物来精确调节胃肠道中的消化过程和其他生理过程，需要通过化学感应细胞连续监测腔内的含量。关于胃肠道腔内化合物的检测，G蛋白偶联受体（GPCR）是令人感兴趣的信号蛋白，因为众所周知其中一些可与大量营养素结合，包括糖，氨基酸和脂质。我们报告说，Olfr78，GPCRs的气味受体（OR）类的成员，在鼠肠中表达。我们的研究结果支持Olfr78被丙酸酯激活的概念，丙酸酯是微生物在结肠中产生的重要营养素。原位杂交和免疫组织化学方法显示，Olfr78在结肠中表达，但在其他胃肠道区隔（例如胃和小肠）中却不存在。在结肠中，Olfr78由位于隐窝内的上皮细胞的一个子集表达。这些细胞具有向隐窝腔突出的顶突。结肠中的Olfr78阳性细胞共表达荷尔蒙肽YY（PYY），这是给定肠内分泌细胞的标志物。结肠上皮肠内分泌细胞中丙酸酯受体Olfr78的表达表明，Olfr78参与调节此类细胞的激素分泌，这是营养化合物引起的。

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