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首页> 外文期刊>Life sciences >Metabolic features of newly established congenic diabetes-prone BB.SHR rat strains.
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Metabolic features of newly established congenic diabetes-prone BB.SHR rat strains.

机译：新近建立的易发糖尿病的BB.SHR大鼠品系的代谢特征。

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The well-known association of hypertension and diabetes mellitus and the lack of suitable animal models to study diabetic hypertension prompted us to transfer 4 chromosomal regions with quantitative trait loci (QTLs) for blood pressure of the spontaneously hypertensive SHR rat onto the genetic background of the diabetes-prone and normotensive BB/OK rat. Four congenic strains developed are named as BB. Sa (Chr.1), BB.Bp2 (Chr.18), BB.1K (Chr.20) and BB.Xs (Chr.X). Because the systolic blood pressure is significantly elevated in all congenics, renal related traits were investigated in serum and urine. Comparing BB/OK and their congenic derivatives, significant differences were found in all serum and in 7 out of 8 urine constituents studied. Most significant differences were found between BB/OK and BB.Bp2 rats. Significant differences were also found between the different congenic strains indicating that each congenic strain has its own phenotype and that each chromosomal region contains most probably further QTLs for some of the traits studied.
机译：高血压和糖尿病的众所周知的关联以及缺乏研究糖尿病高血压的合适动物模型促使我们将4个具有定量特征位点（QTL）的染色体区域转移至自发性高血压SHR大鼠的血压上糖尿病多发和血压正常的BB / OK大鼠。所开发的四个同系菌株被命名为BB。 Sa（Chr.1），BB.Bp2（Chr.18），BB.1K（Chr.20）和BB.Xs（Chr.X）。由于所有同类动物的收缩压均显着升高，因此对血清和尿液中的肾脏相关性状进行了研究。比较BB / OK及其同类衍生物，在所有血清中和研究的8种尿液成分中有7种存在显着差异。在BB / OK和BB.Bp2大鼠之间发现了最显着的差异。在不同的同系品系之间也发现了显着差异，表明每个同系品系都有其自己的表型，并且每个染色体区域对于所研究的某些性状都可能包含更多的QTL。

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