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首页> 外文期刊>Life sciences >Cholinergic and glutamatergic activation reverses working memory failure by hippocampal histamine H1 receptor blockade in rats.
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Cholinergic and glutamatergic activation reverses working memory failure by hippocampal histamine H1 receptor blockade in rats.

机译：胆碱能和谷氨酸能激活逆转大鼠海马组胺H1受体阻滞的工作记忆衰竭。

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摘要

Intrahippocampal administration of the histamine H1 receptor antagonist pyrilamine (3.2-32 ug/ side) but not the histamine H2 receptor antagonist cimetidine (1.0-10 microg/side) increased the number of errors in the working memory task with a three-panel runway setup. The increase in working memory errors induced by intrahippocampal 32 microg/side pyrilamine was significantly reduced by concurrent infusion of the histamine H1 receptor agonist 2-pyridylethylamine (3.2 and 10 microg/side). The cholinesterase inhibitor physostigmine ( 1.0 and 3.2 microg/side) and D-cycloserine (0.32 and 1.0 microg/side), the partial agonist at the glycine binding site on the NMDA receptor/channel complex, reduced the increase in working memory errors induced by intrahippocampal 32 microg/side pyrilamine. These results suggest that the hippocampal histaminergic activity via histamine H1 receptor is necessary for normal working memory processes and that the septohippocampal cholinergic activation and positive modulation of the NMDA receptor/channel through activation of the glycine site can alleviate dysfunction of hippocampal histamine H1 receptor-mediated neurotransmission involved in working memory function.
机译：海马组内注射组胺H1受体拮抗剂吡拉明（3.2-32 ug /侧），但不注射组胺H2受体拮抗剂西咪替丁（1.0-10 microg /侧），增加了三面板跑道设置在工作记忆任务中的错误数量。通过同时输注组胺H1受体激动剂2-吡啶基乙胺（3.2和10微克/侧），可显着减少由海马内32微克/侧吡咯胺引起的工作记忆错误的增加。胆碱酯酶抑制剂毒扁豆碱（1.0和3.2微克/边）和D-环丝氨酸（0.32和1.0微克/边），NMDA受体/通道复合物上甘氨酸结合位点的部分激动剂，减少了由下列物质引起的工作记忆错误的增加：海马内32微克/侧吡咯胺。这些结果表明，通过组胺H1受体进行的海马组胺能活性对于正常的工作记忆过程是必要的，并且隔海马胆碱能的激活和通过甘氨酸位点的激活对NMDA受体/通道的正调节可以减轻海马组胺H1受体介导的功能障碍。神经传递参与工作记忆功能。

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