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首页> 外文期刊>Life sciences >Protective effects of melatonin against ischemia-reperfusion injury in the isolated rat heart.
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Protective effects of melatonin against ischemia-reperfusion injury in the isolated rat heart.

机译：褪黑素对离体大鼠心脏缺血再灌注损伤的保护作用。

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摘要

There has been increased interest in melatonin recently, since it was shown to be a potent scavenger of toxic free radicals. Melatonin has been found to be effective in protecting against pathological states due to reactive oxygen species release. The present study was performed in order to determine whether melatonin or 5-methoxy-carbonylamino-N-acetyl-tryptamine (5-MCA-NAT), a structurally related indole compound, protect against ischemia-reperfusion injury in the isolated rat heart. Wistar rats were treated in vivo with either melatonin (1 or 10 mg/kg, i.p.) or 5-MCA-NAT (10 mg/kg, i.p.) or their vehicle, 30 min before their hearts were excised and perfused according to the Langendorff technique. Two different protocols were then applied. In the first one, a regional ischemia (5 min)-reperfusion (30 min) sequence was performed in order to record incidence and duration of reperfusion arrhythmias. In the second one, infarct size was assessed after a regional ischemia (30 min)-reperfusion (120 min) sequence. Results show a spectacular protection against ischemia-reperfusion injuries (on arrhythmias as well as on infarct size) in rats pre-treated with 10 mg/kg of melatonin or 5-MCA-NAT. In conclusion, both melatonin and its structural analog, 5-MCA-NAT, appear to confer protection against ischemia-reperfusion injury in the isolated rat heart. This observation suggests that melatonin could have a potential clinical application in the treatment of myocardial ischemia, even if the mechanisms underlying this protection remain to be determined.
机译：最近，人们对褪黑激素的兴趣有所增加，因为它被证明是有效清除有毒自由基的物质。已经发现褪黑激素可有效地防止由于活性氧释放引起的病理状态。进行本研究是为了确定褪黑激素或结构相关的吲哚化合物5-甲氧基-羰基氨基-N-乙酰基-色胺（5-MCA-NAT）是否能防止离体大鼠心脏缺血再灌注损伤。根据兰根多夫（Langendorff），在切除心脏并灌注30分钟之前，对Wistar大鼠体内进行褪黑激素（1或10 mg / kg，ip）或5-MCA-NAT（10 mg / kg，ip）或其媒介物体内处理技术。然后应用了两种不同的协议。在第一个实验中，进行局部缺血（5分钟）-再灌注（30分钟）顺序以记录再灌注心律不齐的发生率和持续时间。在第二例中，在局部缺血（30分钟）-再灌注（120分钟）序列后评估梗死面积。结果表明，在用10 mg / kg褪黑素或5-MCA-NAT预处理的大鼠中，具有出色的抗缺血再灌注损伤（对心律失常和梗塞大小的作用）的保护作用。总之，褪黑激素及其结构类似物5-MCA-NAT似乎在离体大鼠心脏中提供了针对缺血-再灌注损伤的保护作用。该观察结果表明，褪黑素在心肌缺血的治疗中可能具有潜在的临床应用，即使这种保护作用的机制尚待确定。

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