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首页> 外文期刊>Life sciences >3,5,3'-Triiodothyronine administered to rat dams during lactation increases milk yield and triglyceride concentration and hastens pups growth.
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3,5,3'-Triiodothyronine administered to rat dams during lactation increases milk yield and triglyceride concentration and hastens pups growth.

机译：哺乳期对大鼠大坝施用3,5,3'-三碘甲状腺氨酸可增加牛奶产量和甘油三酸酯浓度，并加快幼仔的生长。

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摘要

It is known that lactation induces a mild hypothyroid state in rats and other mammals while thyroid hormone administration increases milk secretion in ruminants. The aim of this study was to investigate the effects of a moderate dose of 3,5,3'-triiodothyronine (T3), administered to rat dams during lactation on pups' growth and milk yield and composition. Primiparous Wistar rats with litters adjusted to 10 pups per dam received either tap water or T3 (75 microg/kg x day) in their drinking water from parturition till weaning. Food and water intake of dams and body weight of dams and pups were measured daily. In other groups of rats with similar treatments, milk yield of dams, macronutrient milk composition, and mammary arteriovenous differences for triglycerides (TG) and glucose were also determined. Dams treated with T3 ingested more food and their pups gained more weight than controls. Milk yield, milk TG concentration and glucose extraction by mammary glands were also higher in T3 treated dams. The results show that compensation of the mild hypothyroidism of the lactating rat may contribute to an increase in milk production and lipid levels, leading to an increase in growth of pups.
机译：众所周知，泌乳会在大鼠和其他哺乳动物中引起轻度甲状腺功能减退状态，而甲状腺激素的施用会增加反刍动物的乳汁分泌。这项研究的目的是研究在哺乳期对大鼠大坝施用适量的3,5,3'-三碘甲状腺素（T3）对幼仔的生长，产奶量和组成的影响。从分娩到断奶的初产Wistar大鼠，其产仔数调整为每只大坝10头幼仔，其饮用水中接受自来水或T3（75微克/千克x天）。每天测量水坝的食物和水的摄入量以及水坝和幼崽的体重。在其他接受类似治疗的大鼠组中，也确定了大坝的产奶量，大量营养奶成分以及甘油三酸酯（TG）和葡萄糖的乳腺动静脉差异。用T3处理的水坝摄入了更多的食物，它们的幼崽比对照组的体重增加了。在T3处理的水坝中，牛奶产量，牛奶TG浓度和通过乳腺提取的葡萄糖也较高。结果表明，对哺乳期大鼠的轻度甲状腺功能减退的补偿可能有助于增加牛奶的产量和脂质水平，从而导致幼崽生长的增加。

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