...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell and Tissue Research >Lactoferrin at basal side of mouse mammary epithelium derives in part from stroma cells.
【24h】

Lactoferrin at basal side of mouse mammary epithelium derives in part from stroma cells.

机译：小鼠乳腺上皮基底侧的乳铁蛋白部分来源于基质细胞。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Lactoferrin is synthesized by glandular epithelial cells and neutrophils and is also present on both sides of the mammary epithelium. We have studied the origin of lactoferrin detected in the various compartments of mouse mammary tissue. As revealed by immunogold electron microscopy, lactoferrin is present in mammary epithelial cells and in the basal region of the epithelium, associated with connective tissue and stroma cells at all physiological stages studied. A perturbation of protein synthesis or transport after in vitro treatment with cycloheximide or brefeldin A does not abrogate lactoferrin labelling in the basal region of the epithelium. The expression of lactoferrin has also been observed in the fat pads of mammary glands from mice surgically depleted of epithelial cells. The sealing of one teat for 24 h is accompanied by an increase in both the number of stroma cells and the labelling of myoepithelial cells. Thus, the lactoferrin present in the interstitial space of the mouse mammary epithelium originates in part from stroma cells. Possible roles of lactoferrin at the basal side of the mammary epithelium are discussed.
机译：乳铁蛋白由腺上皮细胞和中性粒细胞合成，也存在于乳腺上皮的两侧。我们研究了在小鼠乳腺组织的各个区室中检测到的乳铁蛋白的来源。免疫金电子显微镜显示，乳铁蛋白存在于乳腺上皮细胞和上皮基底区域，在所研究的所有生理阶段均与结缔组织和基质细胞有关。在用环己酰亚胺或布雷菲德菌素A进行体外治疗后，蛋白质合成或运输的扰动不会消除上皮基底区域的乳铁蛋白标记。乳铁蛋白的表达还可以通过手术切除上皮细胞的小鼠在乳腺的脂肪垫中观察到。一个乳头密封24小时会同时增加基质细胞的数量和肌上皮细胞的标记。因此，存在于小鼠乳腺上皮间隙中的乳铁蛋白部分源自基质细胞。乳铁蛋白在乳腺上皮基底侧的可能作用进行了讨论。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号