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首页> 外文期刊>Cell and Tissue Research >Ultrastructure of interstitial cells of Cajal in myenteric plexus of human colon.
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Ultrastructure of interstitial cells of Cajal in myenteric plexus of human colon.

机译：人结肠肌丛神经中Cajal间质细胞的超微结构。

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The role of the interstitial cells of Cajal (ICC) associated with the myenteric plexus (ICC-MP) as regulators of the motility of the colonic external muscle remains unclear. Ultrastructural studies of myenteric interstitial cells are lacking in human colon. We therefore characterized the distinctive ultrastructure of these cells in the myenteric region of the colon by transmission electron microscopy of the region between the main muscle layers in all parts of the colon in unaffected areas of resected specimens from nine adult human patients. ICC-MP were similar in various colonic regions and had myoid features such as scattered caveolae, prominent intermediate filaments, and cytoplasmic dense bodies. We found characteristic dense membrane-associated bands with a patchy basal lamina, invaginating cellular protrusions (peg and socket junctions) between ICC and between ICC and muscle cells, and close contacts (<100 nm) between ICC and nerves. No gap junctions were observed. Fibroblast-like cells (FLC) were abundant showing well-developed secretory organelles, including coated vesicles, but lacked prominent intermediate filaments and caveolae. FLC had a patchy basal lamina, and peg and socket junctions were observed between them. Macrophage-like cells frequently occurred in close apposition with FLC and, more seldomly, with ICC-MP. The ultrastructure of ICC and FLC in the myenteric region of the human colon thus differs characteristically, but significant overlaps in the ultrastructure between ICC and FLC might complicate any interpretation in pathological ultrastructural studies of the human colonic muscle layer.
机译：与肌间神经丛（ICC-MP）相关的Cajal间质细胞（ICC）作为结肠外肌运动的调节因子的作用尚不清楚。人结肠缺乏肌间质细胞的超微结构研究。因此，我们通过九个成年人类患者切除标本的未受影响区域中结肠各部分主要肌肉层之间区域的透射电镜观察，表征了这些细胞在结肠肌层区域的独特超微结构。 ICC-MP在各个结肠区域相似，并具有肌样特征，例如散布的小窝，突出的中间细丝和胞质致密体。我们发现特征性的致密膜相关带，带有不规则的基底层，在ICC之间以及ICC与肌肉细胞之间侵入细胞突起（钉和窝连接），并且ICC与神经之间紧密接触（<100 nm）。没有观察到间隙连接。成纤维细胞样细胞（FLC）丰富，显示发育良好的分泌细胞器，包括包被的囊泡，但缺乏明显的中间丝和小窝。 FLC有一个不规则的基底层，并且在它们之间观察到了钉子和承窝连接。巨噬细胞样细胞经常与FLC紧密并存，而很少与ICC-MP并存。因此，人结肠肠系膜区域中ICC和FLC的超微结构特征不同，但是ICC和FLC之间超微结构的显着重叠可能会使人结肠肌层的病理超微结构研究中的任何解释变得复杂。

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