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Utilization of in vivo ultrafiltration in biomedical research and clinical applications.

机译:体内超滤技术在生物医学研究和临床应用中的利用。

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摘要

Ultrafiltration (UF) is a filtrate selection method with a wide range of biomedical and clinical applications, including detoxification of blood in hemodialysis and peritoneal dialysis. New is, however, the use of UF as a convenient in vivo sampling method that, for example, has been used in diabetics. Ultrafiltration avoids complicated and time-consuming recovery calculations that are necessary when using in vivo microdialysis, as recoveries of low molecular weight molecules are near 100%. The subcutaneously or intravenously placed UF probes have been studied for off-line sample analysis and for continuous on-line monitoring, in a wide variety of species, including dogs, rats, pigs and humans. This review discusses the potential of in vivo UF as a continuous tissue sampling technique in clinical research areas, and in several major biomedical applications including glucose and lactate monitoring and drug kinetic studies.
机译:超滤(UF)是一种滤液选择方法,具有广泛的生物医学和临床应用,包括血液透析和腹膜透析中的血液排毒。但是,UF是一种方便的体内采样方法,例如已经在糖尿病患者中使用的新方法。超滤避免了使用体内微透析时所需的复杂且费时的回收率计算,因为低分子量分子的回收率接近100%。已经对皮下或静脉内放置的超音波探针进行了研究,以用于离线样本分析和连续在线监测,涉及多种物种,包括狗,大鼠,猪和人。这篇综述讨论了在临床研究领域以及包括葡萄糖和乳酸监测以及药物动力学研究在内的几种主要生物医学应用中,体内超滤作为连续组织采样技术的潜力。

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