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SELENIUM HOMEOSTASIS IN THE CENTRAL NERVOUS SYSTEM OF THE RAT

机译：大鼠中枢神经系统硒稳态

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These experiments have investigated selenium movement between blood and CNS in anaesthetised rats. Each animal was surgically anaesthetised and the left femoral blood vessels cannulated for blood withdrawal and solute infusion. Each rat received 75-selenium as sodium selenite infused in normal saline and experiments lasted between 5 minutes and 5 hours during which blood samples were periodically taken. At termination, the CNS was removed, regionally dissected and analysed with the plasma samples for 75-Se radioactivity by gamma-counting. Data were analysed by graphical analysis. Results showed unidirectional uptake of 75-Se into the CNS and regional differences were not found except for the hypothalamus. On average the CNS influx rate constant (K-in) Was about 7 +/- 1 x 10(-5) ml/min/g. Data suggest that the 75-Se most likely entered the CNS as a free ionic form. [References: 38]
机译：这些实验研究了麻醉大鼠中硒在血液和中枢神经系统之间的移动。对每只动物进行手术麻醉，并穿刺左股血管以抽血和溶质注入。每只大鼠接受以亚硒酸钠形式注入生理盐水中的75硒，实验持续5分钟至5小时，在此期间定期采集血样。终止时，将CNS移出，进行局部解剖，并通过γ计数与血浆样品分析75 Se放射性。数据通过图形分析进行分析。结果显示中枢神经系统单向摄取75-Se，除下丘脑外未发现区域差异。平均而言，CNS流入速率常数（K-in）约为7 +/- 1 x 10（-5）ml / min / g。数据表明75-Se最有可能以游离离子形式进入CNS。 [参考：38]

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