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首页> 外文期刊>Life sciences >NITRIC OXIDE-DEPENDENT SOLUBLE GUANYLATE CYCLASE ACTIVITY IS DECREASED IN PLATELETS FROM MALE NIDDM PATIENTS
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NITRIC OXIDE-DEPENDENT SOLUBLE GUANYLATE CYCLASE ACTIVITY IS DECREASED IN PLATELETS FROM MALE NIDDM PATIENTS

机译：男性NIDDM患者血小板中一氧化氮依赖性可溶性胍盐环化酶活性降低

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摘要

To elucidate the underlying mechanisms of platelet dysfunction in diabetes mellitus, we examined the activity of soluble guanylate cyclase (sGC), a key enzyme in the nitric oxide (NO)-related signalling pathway, in platelets from NIDDM (non-insulin dependent diabetes mellitus) patients. The sGC activity was determined by measuring the amount of cyclic GMP produced in platelet cytosol. In the first study, we investigated the platelet sGC activity in untreated NIDDM patients without diabetic complications. In the male NIDDM patients, sodium nitroprusside (SNP) caused a significantly lower sGC response than that in age-matched control male subjects, while the enzyme activity of female diabetics did not differ from that in the controls. Secondly, we investigated effects of diabetic-associated factors on the enzyme activity in the male NIDDM patients. There was no difference in the SNP-stimulated sGC activity in platelets from male diabetics between with and without retinopathy. In the male diabetic patients with retinopathy, however, the platelet sGC activity was slightly increased by treatment with insulin. Interestingly, the changes in enzyme activity did not correlate with plasma glycosylated hemoglobin Ale levels in diabetic patients. The impairment of the NO-related signalling pathway may contribute to the platelet dysfunction observed in patients with diabetes mellitus. [References: 33]
机译：为了阐明糖尿病患者血小板功能障碍的潜在机制，我们在NIDDM（非胰岛素依赖型糖尿病）患者的血小板中检查了可溶性鸟苷酸环化酶（sGC）（一氧化氮（NO）相关信号通路中的关键酶）的活性。 ） 耐心。 sGC活性是通过测量血小板胞浆中产生的环状GMP的量来确定的。在第一个研究中，我们调查了未经治疗的无糖尿病并发症的NIDDM患者的血小板sGC活性。在男性NIDDM患者中，硝普钠（SNP）引起的sGC响应明显低于年龄匹配的对照组男性，而女性糖尿病患者的酶活性与对照组无差异。其次，我们调查了糖尿病相关因素对男性NIDDM患者酶活性的影响。在有和没有视网膜病变的男性糖尿病患者的血小板中，SNP刺激的sGC活性没有差异。然而，在患有视网膜病变的男性糖尿病患者中，胰岛素治疗可使血小板sGC活性略有增加。有趣的是，糖尿病患者中酶活性的变化与血浆糖基化血红蛋白Ale水平无关。 NO相关信号通路的损伤可能会导致糖尿病患者中观察到的血小板功能障碍。 [参考：33]

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