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首页> 外文期刊>Life sciences >INSULIN-LIKE GROWTH FACTOR-I GIVEN SUBCUTANEOUSLY REDUCES CLINICAL DEFICITS, DECREASES LESION SEVERITY AND UPREGULATES SYNTHESIS OF MYELIN PROTEINS IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
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INSULIN-LIKE GROWTH FACTOR-I GIVEN SUBCUTANEOUSLY REDUCES CLINICAL DEFICITS, DECREASES LESION SEVERITY AND UPREGULATES SYNTHESIS OF MYELIN PROTEINS IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS

机译：像胰岛素样生长因子一样，在实验性自身免疫性脑脊髓炎中成功地减轻了临床缺陷，降低了病变程度并增强了髓鞘蛋白的合成

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To extend our evaluation of insulin-like growth factor-I (IGF-I) treatment for human demyelinating diseases, we compared effects of s.c. and i.v. IGF-I in an in vivo model with lesions resembling those seen in multiple sclerosis. Experimental autoimmune encephalomyelitis (EAE) was induced in Lewis rats with an emulsion containing guinea pig spinal cord and treatment with placebo or with s.c. or i.v. IGF-I was started when definite clinical weakness was present. IGF-I given subcutaneously significantly reduced clinical deficits and lesion severity. The clinical improvement, as measured by clinical deficit scores, stride lengths and exercise wheel rotations, was evident in 48 hrs and was comparable to that produced by the same IGF-I dose administered intravenously. Subcutaneously administered IGF-I also increased relative mRNA levels of myelin basic protein (MBP), proteolipid protein (PLP) and 2',3' cyclic nucleotide 3'-phosphodiesterase (CNP), thereby promoting myelin regeneration. We conclude that s.c. IGF-I produces dramatic improvement in acute, demyelinating EAE. Our results also suggest that this growth factor may be useful in treating multiple sclerosis patients with active demyelination. [References: 19]
机译：为了扩大对人类脱髓鞘疾病的胰岛素样生长因子-I（IGF-I）治疗的评估，我们比较了s.c.和i.v.体内模型中的IGF-I具有与多发性硬化症相似的损伤。用含有豚鼠脊髓的乳剂在Lewis大鼠中诱发实验性自身免疫性脑脊髓炎（EAE），并用安慰剂或s.c.治疗。或i.v.当出现明确的临床无力时开始使用IGF-I。皮下注射IGF-I可显着减少临床缺陷和病变严重程度。通过临床缺陷评分，步幅长度和运动轮旋转来衡量的临床改善在48小时内是显而易见的，并且与静脉注射相同剂量的IGF-1所产生的改善相当。皮下注射的IGF-1也增加了髓磷脂碱性蛋白（MBP），蛋白脂蛋白（PLP）和2'，3'环状核苷酸3'-磷酸二酯酶（CNP）的相对mRNA水平，从而促进了髓磷脂的再生。我们得出的结论是IGF-I在急性脱髓鞘的EAE中产生了显着的改善。我们的结果还表明，该生长因子可能在治疗活动性脱髓鞘的多发性硬化症患者中有用。 [参考：19]

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