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首页> 外文期刊>Life sciences >alpha-Adrenergic and muscarinic cholinergic receptors are not involved in the modulation of the parasympathetic baroreflex by the medial prefrontal cortex in rats.
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alpha-Adrenergic and muscarinic cholinergic receptors are not involved in the modulation of the parasympathetic baroreflex by the medial prefrontal cortex in rats.

机译：α-肾上腺素能和毒蕈碱能的胆碱能受体不参与大鼠前额内侧皮层对副交感神经反射的调节。

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The medial prefrontal cortex (MPFC) is involved in cardiovascular control and baroreflex modulation. Recent studies indicated that stimulation of MPFC muscarinic receptors causes hypotensive responses whereas stimulation of alpha1- but not of alpha2-adrenoceptors causes pressor responses in unanesthetized rats. It has also been shown that the MPFC is involved in the modulation of the parasympathetic component of the baroreflex in rats. We report that bilateral injections of CoCl2 in the ventral portion of the MPFC (vMPFC) reduced the parasympathetic component of the baroreflex, thus confirming the involvement of local synapses. We further evaluated the effect of the pharmacologic block of vMPFC alpha1- or alpha2-adrenoceptors and muscarinic receptors on the vMPFC-related modulation of the parasympathetic component of the baroreflex in unanesthetized rats. Bilateral microinjections of 10 nmol of the selective alpha1-adrenoceptor antagonist WB4101 or 10 nmol of the selective alpha2-adrenoceptors antagonist RX821002 into the MPFC did not affect the baroreflex. Bilateral microinjections of 9 nmol of the muscarinic antagonist atropine also did not affect baroreflex activity. The present results indicate that although vMPFC alpha-adrenergic and muscarinic receptors are involved in cardiovascular regulation, they do not mediate the vMPFC-related modulation of the parasympathetic component of the baroreflex.
机译：内侧前额叶皮层（MPFC）参与心血管控制和压力反射调节。最近的研究表明，对MPFC毒蕈碱受体的刺激会引起低血压反应，而对α1-肾上腺素受体的刺激却不会引起α2-肾上腺素受体的刺激，从而在未麻醉的大鼠中引起升压反应。还已经表明，MPFC参与了大鼠压力反射的副交感神经成分的调节。我们报告说，在MPFC（vMPFC）的腹侧双侧注射CoCl2减少了压力反射的副交感成分，从而证实了局部突触的参与。我们进一步评估了vMPFCα1或α2肾上腺素能受体和毒蕈碱受体的药理学阻滞对未麻醉大鼠压力反射副交感成分的vMPFC相关调节的影响。将10 nmol的选择性α1-肾上腺素受体拮抗剂WB4101或10 nmol的选择性α2-肾上腺素受体拮抗剂RX821002双侧显微注射到MPFC中不会影响压力反射。毒蕈碱拮抗剂阿托品的9nmol双侧显微注射也不会影响压力反射活性。目前的结果表明，尽管vMPFCα-肾上腺素和毒蕈碱受体参与了心血管调节，但它们并未介导压力感受性反射的副交感成分的vMPFC相关调节。

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