ENZYMATIC OXIDATION OF THE DOPAMINERGIC NEUROTOXIN, 1(R),2(N)-DIMETHYL-6,7-DIHYDROXY-1,2,3,4,-TETRAHYDROISOQUINOLINE, INTO 1,2(N)-DIMETHYL-6,7-DIHYDROXYISOQUINOLINIUM ION

Naoi M.; Zhang JH.; Takahashi T.; Deng YL.; Dostert P.; Maruyama W.

首页> 外文期刊>Life sciences >ENZYMATIC OXIDATION OF THE DOPAMINERGIC NEUROTOXIN, 1(R),2(N)-DIMETHYL-6,7-DIHYDROXY-1,2,3,4,-TETRAHYDROISOQUINOLINE, INTO 1,2(N)-DIMETHYL-6,7-DIHYDROXYISOQUINOLINIUM ION

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ENZYMATIC OXIDATION OF THE DOPAMINERGIC NEUROTOXIN, 1(R),2(N)-DIMETHYL-6,7-DIHYDROXY-1,2,3,4,-TETRAHYDROISOQUINOLINE, INTO 1,2(N)-DIMETHYL-6,7-DIHYDROXYISOQUINOLINIUM ION

机译：多巴能神经毒素1（R），2（N）-二甲基-6,7-二羟基-1,2,3,4，-四氢异喹啉的酶氧化成1,2（N）-二甲基-6,7-二羟基异喹啉离子

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The dopamine-derived alkaloid, 1(R),2(N)-dimethyl-6,7-dihydroxy-1,2,3,4 tetrahydroisoquinoline [N-methyl(R)salsolinol] was found to be oxidized enzymically into the more cytotoxic species, 1,2(N)-dimethyl-6,7-dihydroxyiso-quinolinium ion, using enzyme sample prepared from human brain cortex. The values of the Michaelis constant and of the maximum velocity were 912 mu M and 1368 pmol/min/mg protein, respectively. The enzyme was not inhibited by inhibitors of monoamine oxidase, but was sensitive to semicarbazide. The oxidation is discussed in relation to the dopaminergic neurotoxicity of N-methyl(R)salsolinol. [References: 20]

机译：发现多巴胺衍生的生物碱1（R），2（N）-二甲基-6,7-二羟基-1,2,3,4四氢异喹啉[N-甲基（R）salsolinol]被酶氧化成更多的生物碱。细胞毒性物质1,2（N）-二甲基-6,7-二羟基异喹啉离子，使用人类大脑皮层制备的酶样品。米氏常数和最大速度分别为912μM和1368pmol / min / mg蛋白。该酶不受单胺氧化酶抑制剂的抑制，但对氨基脲敏感。讨论了与N-methyl（R）salsolinol的多巴胺能神经毒性有关的氧化反应。 [参考：20]

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《Life sciences》 |1995年第11期|共6页
作者
Naoi M.; Zhang JH.; Takahashi T.; Deng YL.; Dostert P.; Maruyama W.;
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正文语种 eng
中图分类生命的起源;生命科学总论;
关键词
N-methylsalsolinol; Semicarbazide-sensitive oxidase; 1; 2-dimethyl-6; 7-dihydroxy-isoquinolinium; Monoamine-oxidase; Alkaloids; Brains; Mptp;

机译：N-methylsalsolinol;对氨基脲敏感的氧化酶;1;2-二甲基-6;7-二羟基异喹啉;单胺氧化酶;生物碱;脑;Mptp;

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1. ENZYMATIC OXIDATION OF THE DOPAMINERGIC NEUROTOXIN, 1(R),2(N)-DIMETHYL-6,7-DIHYDROXY-1,2,3,4,-TETRAHYDROISOQUINOLINE, INTO 1,2(N)-DIMETHYL-6,7-DIHYDROXYISOQUINOLINIUM ION [J] . Naoi M., Zhang JH., Takahashi T., Life sciences . 1995,第11期

机译：多巴能神经毒素1（R），2（N）-二甲基-6,7-二羟基-1,2,3,4，-四氢异喹啉的酶氧化成1,2（N）-二甲基-6,7-二羟基异喹啉离子
2. The influence of acute and chronic administration of 1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline on the function of the nigrostriatal dopaminergic system in rats. [J] . Lorenc-Koci E, Antkiewicz-Michaluk L, Kaminska A, Neuroscience: An International Journal under the Editorial Direction of IBRO . 2008,第4期

机译：急慢性给药1,2-二甲基-6,7-二羟基-1,2,3,4-四氢异喹啉对大鼠黑质纹状体多巴胺能系统功能的影响。
3. Dopamine-derived endogenous 1(R),2(N)-dimethyl-6,7-dihydroxy- 1,2,3,4-tetrahydroisoquinoline, N-methyl-(R)-salsolinol, induced parkinsonism in rat: biochemical, pathological and behavioral studies. [J] . Naoi M, Maruyama W, Dostert P, Brain research . 1996,第2期

机译：多巴胺衍生的内源性1（R），2（N）-二甲基-6,7-二羟基-1,2,3,4-四氢异喹啉，N-甲基-（R）-salsolinol在大鼠中诱发帕金森氏症：生化，病理和行为研究。
4. ELECTROCHEMICALLY-MEDIATED LI+ CHELATION BY 1,2,3,4-TETRAHYDRO-6,7- DIMETHOXY-1,1,4,4- TETRAMETHYLNAPHTHALENE: IN SITU STRUCTURAL CHARACTERIZATION AND ENERGY STORAGE APPLICATIONS [C] . Emily V. Carino, Jakub Staszak-Jirkovsky, Rajeev S. Assary American Chemical Society National Meeting Exposition . 2015

机译：通过1,2,3,4-四氢-6,7-二甲氧基-1,4,4-四甲基萘的电化学介导的Li +螯合剂：原位结构表征和能量储存应用
5. Influence of glutathione and L-cysteine on the oxidation chemistry of 1-methyl-6-hydroxy-1,2,3,4-tetrahydro-beta-carboline: Chemistry and putative oxidative metabolites of 1-methyl-6-hydroxy-1,2,3,4-tetrahydro-beta-carboline of potential relevance to the addictive and neurodegenerative consequences of ethanol abuse. [D] . Han, Qingping. 1995

机译：谷胱甘肽和L-半胱氨酸对1-甲基-6-羟基-1,2,3,4-四氢-β-咔啉的氧化化学的影响：1-甲基-6-羟基-1的化学和假定的氧化代谢产物2,3,4-四氢-β-咔啉可能与滥用乙醇的成瘾和神经退行性后果有关。
6. Enzymatic conversion of benzo(a)pyrene leading predominantly to the diol-epoxide r-7t-8-dihydroxy-t-910-oxy-78910-tetrahydrobenzo(a)pyrene through a single enantiomer of r-7 t-8-dihydroxy-78-dihydrobenzo(a)pyrene. [O] . S K Yang, D W McCourt, P P Roller, 1976

机译：通过单一对映异构体将苯并（a）py主要转化为二醇-环氧化物r-7t-8-二羟基-t-910-氧基-78910-四氢苯并（a）py r-7t-8-二羟基-78-二氢苯并（a）py的合成。
7. CKD-712, (S)-1-(α-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, Inhibits the NF-κB Activation and Augments Akt Activation during TLR4 Signaling [O] . Lee, Jeonggi, Yang, Eun-Jeong, Shin, Jeon-Soo, 2011

机译：CKD-712，（S）-1-（α-萘甲基）-6,7-二羟基-1,2,3,4-四氢异喹啉在TLR4信号传导期间抑制NF-κB激活并增强Akt激活
8. Preparation and Determination of Absolute Rotations and Configurations of 6,7-Dimethoxy-1,2-Dimethyl-exo-2-Benzonorbornenyl Derivatives. [R] . Goering, H. L., Backus, A. C., Chang, C. S., 1974

机译：6,7-二甲氧基-1,2-二甲基 - 外-2-苯并乙烯基衍生物的绝对旋转和构型的制备和测定。

ENZYMATIC OXIDATION OF THE DOPAMINERGIC NEUROTOXIN, 1(R),2(N)-DIMETHYL-6,7-DIHYDROXY-1,2,3,4,-TETRAHYDROISOQUINOLINE, INTO 1,2(N)-DIMETHYL-6,7-DIHYDROXYISOQUINOLINIUM ION

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