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首页> 外文期刊>Life sciences >Fetal exposure to a maternal low protein diet impairs nephrogenesis and promotes hypertension in the rat.
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Fetal exposure to a maternal low protein diet impairs nephrogenesis and promotes hypertension in the rat.

机译：胎儿暴露于母体低蛋白饮食会损害肾生成并促进大鼠高血压。

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摘要

Epidemiological evidence suggests that hypertension and coronary heart disease are programmed by exposure to a poor diet during intrauterine life. It has been proposed that the prenatal environment may exert an adverse effect on the development of the kidney and hence later control of blood pressure. These assertions are supported by animal experiments. In the rat, fetal exposure to a maternal low protein diet is associated with disproportionate patterns of fetal growth and later elevation of blood pressure. Pregnant female rats were fed control (18% casein) or low protein diets throughout pregnancy, or during specific periods. Nephron number was determined at day 20 gestation, full term and 4 weeks of age. Exposure to low protein throughout gestation, or in mid-late gestation increased total nephron number at day 20. By term nephron number was reduced, relative to controls, in rats that were undernourished between days 8-14 or 15-22 gestation. At 4 weeks postnatally rats exposed to low protein throughout fetal life had a reduced (13%) nephron complement and blood pressures 13 mmHg above control animals. Lower renal size and elevated blood pressure persisted to 19 weeks of age, at which time glomerular filtration rate was normal. The data are consistent with the hypothesis that maternal undernutrition may programme the renal nephron number and hence impact upon adult blood pressure and the development of renal disease.
机译：流行病学证据表明，高血压和冠心病是通过在宫内生活中饮食不当造成的。已经提出，产前环境可能对肾脏的发育产生不利影响，从而对后来的血压控制产生不利影响。这些断言得到动物实验的支持。在大鼠中，胎儿暴露于母体低蛋白饮食会导致胎儿生长方式不均衡以及血压升高。怀孕的雌性大鼠在整个怀孕期间或特定时期都接受对照（18％酪蛋白）或低蛋白饮食喂养。在妊娠第20天，足月和4周龄时测定肾单位数目。在整个妊娠过程中或妊娠中后期暴露于低蛋白会增加第20天的总肾单位数。相对于对照组，长期妊娠8-14天或15-22天之间营养不良的大鼠的肾脏单位数减少了。出生后4周，整个胎儿生命中暴露于低蛋白的大鼠肾脏补体减少（13％），血压比对照组动物高13 mmHg。较低的肾脏大小和血压升高持续到19周龄，此时肾小球滤过率正常。数据与以下假设相吻合，即孕产妇营养不良可能会影响肾脏的肾单位数目，从而影响成人血压和肾脏疾病的发展。

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