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首页> 外文期刊>Life sciences >THE EFFECTS OF TROPICAMIDE ON MYDRIASIS IN YOUNG RATS EXHIBITING A NATURAL DEFICIT IN PASSIVE-AVOIDANCE RESPONDING
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THE EFFECTS OF TROPICAMIDE ON MYDRIASIS IN YOUNG RATS EXHIBITING A NATURAL DEFICIT IN PASSIVE-AVOIDANCE RESPONDING

机译：对乙酰氨基吡咯烷酰胺对幼鼠表现出的被动反应的自然缺陷的影响

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The young rat at post-natal day 18-22 exhibits a natural deficit in passive-avoidance responding that can be corrected with the acute systemic administration of different cholinomimetic drugs, such as tacrine. In order to evaluate the generality of this apparent cholinergic hypofunction, different doses of the anticholinergic agent tropicamide, were administered either systemically or dropped directly into the eye of young or adult rats. Tropicamide produced mydriasis in a dose-dependent manner. The ED50 for tropicamide dropped into the eye was 0.025% for adult rats and 0.12% for young rats. When doses between 0.3 and 100 mg/kg were delivered systemically, the mean time course for recovery to baseline pupil size was accelerated in young rats. The average time to recovery across all doses was 112 +/- 27 min (mean +/- SE) for young rats and 274 +/- 70 min for adults. When subcutaneous tacrine was given immediately to young rats after training in a passive-avoidance response (PAR) task, retention was enhanced at testing 24 hours later in a dose-dependent manner. The response latencies were statistically different from saline-treated controls at doses of 0.003 and 0.01 mg/kg. This was not observed in adult rats. Taken together these results suggest that the PAR, along with the mydriacyl response of the young rat to tropicamide, may be regulated by a system of subsensitive cholinergic receptors. [References: 17]
机译：幼鼠在出生后第18-22天表现出被动回避反应的自然缺陷，可以通过急性全身性给药不同的拟胆碱药物（例如他克林）来纠正这一缺陷。为了评估这种明显的胆碱能功能低下的普遍性，可以全身或直接滴入幼年或成年大鼠的眼中，施用不同剂量的抗胆碱能药tropicamide。 Tropicamide以剂量依赖性方式产生散瞳。掉入眼中的托吡卡胺的ED50对成年大鼠为0.025％，对幼鼠为0.12％。当全身给药0.3至100 mg / kg的剂量时，年轻大鼠中恢复到基线瞳孔大小的平均时间进程会加快。所有剂量的平均恢复时间对于年轻大鼠为112 +/- 27分钟（平均+/- SE），对于成人为274 +/- 70分钟。当在被动回避反应（PAR）任务中训练后立即给年轻大鼠皮下注射他克林时，在24小时后的测试中，以剂量依赖的方式增强了保留能力。在0.003和0.01 mg / kg的剂量下，反应潜伏期与生理盐水对照组相比有统计学差异。在成年大鼠中未观察到这一点。综上所述，这些结果表明，PAR，以及幼鼠对托品酰胺的肉豆蔻酰基反应，可能受亚敏感胆碱能受体系统的调节。 [参考：17]

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