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首页> 外文期刊>Cell biology international. >The response of primary articular chondrocytes to micrometric surface topography and sulphated hyaluronic acid-based matrices.
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The response of primary articular chondrocytes to micrometric surface topography and sulphated hyaluronic acid-based matrices.

机译：初级关节软骨细胞对微米表面形貌和硫酸化透明质酸基基质的反应。

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摘要

Understanding the response of chondrocytes to topographical cues and chemical patterns could provide invaluable information to advance the repair of chondral lesions. We studied the response of primary chondrocytes to nano- and micro-grooved surfaces, and sulphated hyaluronic acid (HyalS). Cells were grown on grooves ranging from 80 nm to 9 microm in depth, and from 2 microm to 20 microm in width. Observations showed that the cells did not spread appreciably on any groove size, or alter morphology or F-actin organization, although cells showed accelerated movement on 750 nm deep grooves in comparison to flat surfaces. On chemical patterns, the cells migrated onto, and preferentially attached to, HyalS and showed a greater degree of spreading and F-actin re-arrangement. This study shows that 750 nm deep grooves and sulphated hyaluronic acid elicit responses from primary chondrocytes, and this could have implications for the future direction of cartilage reconstruction and orthopaedic treatments in general.
机译：了解软骨细胞对地形线索和化学模式的反应可能会提供宝贵的信息，以促进软骨损伤的修复。我们研究了原代软骨细胞对纳米和微沟槽表面以及硫酸化透明质酸（HyalS）的反应。细胞生长在深度从80 nm到9微米，宽度从2微米到20微米不等的凹槽中。观察结果表明，尽管与平坦表面相比，细胞在750 nm深的沟槽上显示出加速的运动，但它们在任何沟槽尺寸上都没有明显散布，也没有改变形态或F-肌动蛋白的组织。在化学模式上，细胞迁移到HyalS并优先附着在HyalS上，并表现出更大程度的扩散和F-肌动蛋白重排。这项研究表明，750 nm深的凹槽和硫酸化的透明质酸会引起原代软骨细胞的反应，这可能对软骨重建和整形外科治疗的未来方向产生影响。

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