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首页> 外文期刊>Cell biology international. >Landmarks in the first hundred years of primary (9+0) cilium research.
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Landmarks in the first hundred years of primary (9+0) cilium research.

机译：主要（9 + 0）纤毛研究的头一百年具有里程碑意义。

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Primary cilia have had a long research history since 1898, but only in the last few years have investigations become intense. Only a few people took an interest in them until recently, when the consequences of their agenesis or dysfunction suddenly became apparent to all. Their function changed overnight from being speculative to being fully "acknowledged" as sensory, and the consequence of their lacking sensory function(s) led to a bonanza for cell and molecular biologists interested in the impact on clinical disease and disorder. Furthermore, once the medical profession had insight not just into the etiology of an extremely rare syndrome (situs inversus), but into one as prevalent as polycystic kidney disease, furious research activity sprang up in numerous centres, symposium were convened, special sessions arranged, and topical reviews written in all sorts of journals. Without an understanding of the history of research about this organelle, many reviews gave little credit to those who had persevered earlier to make key advances in primary cilium research, and most ignore the wealth of information on them that has relevance to fundamental (cell) biology as well as to medicine. Some of the "landmarks" presented here will hopefully provide a little guidance and a better perspective.
机译：自1898年以来，原发性纤毛的研究历史就很长，但是直到最近几年，调查才变得更加激烈。直到最近，它们的发育不全或功能障碍的后果突然对所有人都很明显，只有少数人对它们感兴趣。它们的功能在一夜之间从推测性转变为完全“确认”为感觉，并且它们缺乏感觉功能的结果导致了对对临床疾病和病症的影响感兴趣的细胞和分子生物学家的欣欣向荣。此外，一旦医学界不仅对一种极为罕见的综合征（原位反转）的病因学有所了解，而且对一种多囊性肾脏病也很普遍的见识，就在许多中心展开了激烈的研究活动，召开了座谈会，安排了特别会议，以及在各种期刊中撰写的主题评论。在不了解有关该细胞器的研究历史的情况下，许多评论对那些较早地坚持在初级纤毛研究中取得关键进展的人并没有给予什么赞誉，而大多数人则忽略了与基础（细胞）生物学相关的大量信息。以及医学。此处介绍的一些“地标”有望提供一些指导和更好的视角。

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