A mutant strain (LEC) of rat with low degree of zinc-induced hepatic metallothionein gene expression.

Yamada T; Muramatsu Y; Miwa Y; Kim JK; Cai Y; Wei K; Matsumoto K

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A mutant strain (LEC) of rat with low degree of zinc-induced hepatic metallothionein gene expression.

机译：具有低程度锌诱导的肝金属硫蛋白基因表达的大鼠突变株（LEC）。

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A mutant strain (LEC) of rats was found to possess the feature of low degree of the zinc-induced hepatic metallothionein (MT) gene expression due to an alteration of the transcription factor concerned in the gene expression. Northern blot analyses showed that the amount of MT-1 mRNA induced by intraperitoneal zinc injection is smaller in LEC mutant rat liver than in normal rat liver, while the amount of MT-1 mRNA induced by copper injection is indistinguishable between LEC and normal rat livers. Gel retardation assays showed that LEC and normal rat livers are different in the nuclear protein which binds to the metal-responsive element (MRE) of the MT gene in a zinc-dependent manner, and that the efficiency of the zinc-dependent binding of the nuclear protein to the MRE is lower in LEC rat liver than in normal rat liver. LEC rat should provide a useful model to understand the transcription factor concerned in the MT gene expression by zinc.

机译：发现大鼠突变株（LEC）由于与基因表达有关的转录因子的改变而具有低程度的锌诱导的肝金属硫蛋白（MT）基因表达的特征。 Northern印迹分析显示，在LEC突变大鼠肝脏中，腹膜内注射锌诱导的MT-1 mRNA量比正常大鼠肝脏少，而在LEC和正常大鼠肝脏之间，通过铜注射诱导的MT-1 mRNA量却难以区分。。凝胶阻滞试验表明，LEC和正常大鼠肝脏的核蛋白以锌依赖的方式与MT基因的金属反应元件（MRE）结合，而锌依赖的结合效率却不同。 LEC大鼠肝脏中MRE的核蛋白低于正常大鼠肝脏。 LEC大鼠应提供一个有用的模型，以了解锌参与MT基因表达的转录因子。

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《Life sciences》 |1995年第16期|共10页
作者
Yamada T; Muramatsu Y; Miwa Y; Kim JK; Cai Y; Wei K; Matsumoto K;
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正文语种 eng
中图分类生命的起源;生命科学总论;
关键词
Gene Expression; Liver; Metallothionein; Rats; Mutant Strains; Zinc; RNA; Messenger; 基因表达; 肝; 金属硫蛋白; 大鼠; 突变系; 锌;

机译：Gene Expression;Liver;Metallothionein;Rats;Mutant Strains;Zinc;RNA;Messenger;基因表达;肝;金属硫蛋白;大鼠;突变系;锌;

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A mutant strain (LEC) of rat with low degree of zinc-induced hepatic metallothionein gene expression.

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