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Screening of medicinal plant extracts for antioxidant activity.

机译:筛选药用植物提取物的抗氧化活性。

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The methanol extracts of nine medicinal plants traditionally used in Chinese medicine were screened for antioxidant activity versus resveratrol, which has been shown to protect cells from oxidative damage [Toxicol. Lett. 102 (1998) 5]. Most of the plant extracts used in this study inhibited the H(2)O(2)-induced apoptosis of Chinese hamster lung fibroblast (V79-4) cells. The extracts of Areca catechu var. dulcissima, Paeonia suffruticosa, Alpinia officinarum, Glycyrrhiza uralensis and Cinnamomun cassia strongly enhanced viability against H(2)O(2)-induced oxidative damage in V79-4 cells. Relatively high levels of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity were detected in extracts of Areca catechu var. dulcissima, Paeonia suffruticosa and Cinnamomun cassia (IC(50) < 6.0 microg/ml). The activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) were dose-dependently enhanced in V79-4 cells treated with most of the plant extracts. The extracts of Areca catechu var. dulcissima showed higher antioxidant activity than resveratrol in all experiments. These results suggest that the plant extracts prevent oxidative damage in normal cells probably because of their antioxidant characteristics.
机译:相对于白藜芦醇,对九种传统用于中药的药用植物的甲醇提取物进行了抗氧化活性筛选,研究表明该白藜芦醇可以保护细胞免受氧化损伤[Toxicol。来吧102(1998)5]。在这项研究中使用的大多数植物提取物抑制H(2)O(2)诱导的中国仓鼠肺成纤维细胞(V79-4)细胞凋亡。槟榔槟榔提取物。 dulcissima,e药,Alpinia officinarum,甘草和肉桂肉桂强烈增强了抵抗H(2)O(2)诱导的V79-4细胞氧化损伤的活力。在槟榔槟榔提取物中检测到相对较高水平的1,1-二苯基-2-吡啶并肼基(DPPH)自由基清除活性。 dulcissima,Paeonia suffruticosa和肉桂肉桂(IC(50)<6.0 microg / ml)。在大多数植物提取物处理过的V79-4细胞中,超氧化物歧化酶(SOD),过氧化氢酶(CAT)和谷胱甘肽过氧化物酶(GPX)的活性呈剂量依赖性增强。槟榔槟榔提取物。在所有实验中,杜鹃花显示出比白藜芦醇更高的抗氧化活性。这些结果表明该植物提取物可能由于其抗氧化特性而防止了正常细胞的氧化损伤。

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