• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >Angiotensin peptides modulatory system: how is it implicated in the control of seizure susceptibility?
【24h】

Angiotensin peptides modulatory system: how is it implicated in the control of seizure susceptibility?

机译：血管紧张素肽调节系统：它与癫痫发作易感性有何关系？

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Accumulated studies support the concept that angiotensin peptides, ANG II, ANG III, and ANG IV act as neurotransmitters or neuromodulators in specific neuronal pathways in the brain stem, the hypothalamus, and the forebrain. They have been implicated in the regulation of several physiological processes, particularly in excitable brain structures that express high concentration of their receptors. With the help of pharmacological approaches it was shown that angiotensin peptides appear to be anticonvulsant in a variety of experimental seizure models. Thus, ANG II increases the threshold for pentylenetetrazol (PTZ)-, bicuculline-and picrotoxin-induced seizures in mice. It also attenuates the intensity of clonic seizures evoked by PTZ and 3-mercaptopropionic acid and is effective in the maximal electroshock test. Furthermore, ANG II, ANG III, and ANG IV protect against the clonic convulsions in the PTZ kindling model of epilepsy in mice. From the accumulated results it could be assumed that the angiotensin peptides appear to realize their effects acting directly on their receptors (AT(1), AT(2) and AT(4)) and through close interaction with different neurotransmittereuromodulator systems as dopamine (DA)-, gamma-aminobutyric acid (GABA)-and adenosine. This may contribute to a new potential use of angiotensin drugs either alone or in combination with other neuroprotective agents acting through the above mentioned systems, thus providing a more rational strategy for the treatment of neurodegenerative disorders such as epilepsy.
机译：积累的研究支持血管紧张素肽，ANG II，ANG III和ANG IV在脑干，下丘脑和前脑中特定神经元通路中充当神经递质或神经调节剂的概念。它们与几种生理过程的调节有关，特别是表达高浓度受体的兴奋性大脑结构。在药理学方法的帮助下，血管紧张素肽似乎在多种实验性癫痫发作模型中具有抗惊厥作用。因此，ANG II增加了戊四氮（PTZ）-，双小分子-和微毒素诱导的小鼠癫痫发作的阈值。它还减弱了PTZ和3-巯基丙酸引起的阵挛性癫痫发作的强度，并且在最大电击试验中有效。此外，ANG II，ANG III和ANG IV可以防止小鼠癫痫的PTZ点燃模型中的阵挛性惊厥。从累积的结果可以假定，血管紧张素肽似乎实现了直接作用于其受体（AT（1），AT（2）和AT（4））的作用，并通过与不同的神经递质/神经调节剂系统（如多巴胺）紧密相互作用而实现（DA）-，γ-氨基丁酸（GABA）-和腺苷。这可能有助于单独或与通过上述系统起作用的其他神经保护剂组合使用血管紧张素药物的新的潜在用途，从而为治疗神经退行性疾病例如癫痫病提供了更合理的策略。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号