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Sex differences in behavioral effects of cannabinoids.

机译：大麻素行为影响的性别差异。

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摘要

This review summarizes the existing literature on sex differences in the effects of cannabinoid drugs on behavior, primarily in the adult rodent. These preclinical studies, taken together with preliminary reports of sex differences in cannabinoid effects in humans, suggest that sex of subject may be an important modulating factor in a variety of cannabinoid effects. When sex differences are found, females are usually more sensitive than males to cannabinoids. Both pharmacokinetic and pharmacodynamic variables may contribute to sex differences in behavioral effects of cannabinoids. Given the significant therapeutic potential of cannabinoid agonists and antagonists--as well as their widespread recreational use--it will be important to determine the reliability and functional significance of, as well as mechanisms underlying sex differences in cannabinoid effects.
机译：这篇综述总结了有关大麻素对行为的影响（主要是在成年啮齿动物中）的性别差异的现有文献。这些临床前研究与人类对大麻素作用的性别差异的初步报道一起表明，受试者的性别可能是各种大麻素作用的重要调节因素。当发现性别差异时，女性通常比男性对大麻素更敏感。药代动力学和药效动力学变量都可能导致大麻素行为影响的性别差异。鉴于大麻​​素激动剂和拮抗剂的巨大治疗潜力以及广泛的娱乐用途，确定大麻素作用的性别差异的可靠性和功能意义以及潜在机制至关重要。

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