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首页> 外文期刊>Life sciences >L-carnitine and propionyl-L-camitine improve endothelial dysfunction in spontaneously hypertensive rats: Different participation of NO and COX-products
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L-carnitine and propionyl-L-camitine improve endothelial dysfunction in spontaneously hypertensive rats: Different participation of NO and COX-products

机译：L-肉碱和丙酰基-L-肉碱改善自发性高血压大鼠的内皮功能障碍：NO和COX产物的参与不同

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L-carnitine and propionyl-L-carnitine are supplements to therapy in cardiovascular pathologies. Their effect on endothelial dysfunction in hypertension was studied after treatment with either 200 mg/kg of L-carnitine or propionyl-L-carnitine during 8 weeks of spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats (WXY). Endothelial function was assessed in aortic rings by carbachol-induced relaxation (CCh 10(-8) to 10(-4) M) and factors involved were characterized in the presence of the inhibitors: L-NAME, indomethacin, the TXA(2)/ PGH(2) Tp receptor antagonist ICI-192,605 and the thromboxane synthetase inhibitor-Tp receptor antagonist, Ro-68,070. The effect on phenylephrine-induced contractions was also observed. To identify the nature of vasoactive COX-derived products, enzyme-immunoassay of incubation media was assessed. Involvement of reactive oxygen species was evaluated by incubating with superoxide dismutase and catalase. Nitric oxide production was evaluated by serum concentration of NO2+NO3. Treatment with both compounds improved endothelial function of rings from SHR without blood pressure change. Propionyl-L-carnitine increased NO participation in WKY and SHR. L-carnitine reduced endothelium-dependent responses to CCh in WKY due to an increase of TXA(2) production. In both SHR and WKY, L-carnitine enhanced concentration of PGI(2) and increased participation of NO. Results in the presence of SOD plus catalase show that it might be related to antioxidant properties of L-carnitine and propionyl-L-carnitine. Comparison between the effect of both compounds shows that both may reduce reactive oxygen species and increase NO participation in endothelium-dependent relaxations in SHR. However, only L-carnitine was able to increase the release of the vasodilator PGI(2) and even enhanced TXA(2) production in normotensive rats. (c) 2005 Elsevier Inc. All rights reserved.
机译：L-肉碱和丙酰-L-肉碱是心血管疾病治疗的补充。在自发性高血压大鼠（SHR）和血压正常的Wistar Kyoto大鼠（WXY）的8周内，用200 mg / kg的L-肉碱或丙酰-L-肉碱治疗后，研究了它们对高血压内皮功能的影响。通过卡巴胆碱引起的舒张（CCh 10（-8）至10（-4）M）评估主动脉环中的内皮功能，并在以下抑制剂的存在下表征涉及的因子：L-NAME，消炎痛，TXA（2） / PGH（2）Tp受体拮抗剂ICI-192,605和血栓烷合成酶抑制剂-Tp受体拮抗剂Ro-68,070。还观察到对苯肾上腺素引起的收缩的影响。为了确定血管活性COX衍生产品的性质，评估了孵育培养基的酶免疫法。通过与超氧化物歧化酶和过氧化氢酶孵育来评估活性氧的参与度。一氧化氮的产生通过血清中NO2 + NO3的浓度进行评估。两种化合物的治疗均改善了SHR产生的环的内皮功能，而无血压变化。丙酰-L-肉碱增加NO参与WKY和SHR。由于增加了TXA（2）的生产，左旋肉碱减少了WKY中对CCh的内皮依赖性反应。在SHR和WKY中，左旋肉碱均增加PGI（2）的浓度并增加NO的参与。 SOD加过氧化氢酶存在下的结果表明，它可能与L-肉碱和丙酰基-L-肉碱的抗氧化特性有关。两种化合物的作用之间的比较表明，两者均可以减少活性氧，并增加NO参与SHR的内皮依赖性舒张。但是，只有L-肉碱能够增加血压正常大鼠中血管扩张剂PGI（2）的释放，甚至增强TXA（2）的产生。 （c）2005 Elsevier Inc.保留所有权利。

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