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首页> 外文期刊>Life sciences >Effects of prenatal cocaine, morphine, or both on postnatal opioid (mu) receptor development.
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Effects of prenatal cocaine, morphine, or both on postnatal opioid (mu) receptor development.

机译：产前可卡因，吗啡或两者对产后阿片样物质（μ）受体发育的影响。

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We studied the effects of prenatal cocaine and morphine given separately and in combination on the (1) postnatal brain mu-opioid receptor development and (2) interaction of dopamine with mu receptors. Pregnant rats received single daily intraperitoneal (I.P.) injections of saline, cocaine (20 mg/kg), morphine (2 mg/kg), or the combination of both drugs from day 13 to day 20 of gestation. Postnatal days (P) 1, 7, 14, and 28, whole brains were analyzed for opioid receptor binding and mu mRNA. Prenatal cocaine administered by itself had no significant effect on the ontogeny of brain mu receptors on all the days studied when compared to controls. The morphine-treated group showed a significant increase in mu receptor binding on P1 and P7. Exposure to both cocaine and morphine showed a significant increase in mu receptor density on P1 and P7. In addition, there was also a significant increase in MOR mRNA in both the morphine alone and combination groups. Pretreatment with dopamine D2 receptor antagonist (sulpiride, 20 mg/kg) prior to drug administration showed decreased mu receptor binding on P1 and P7. These results suggest that prenatal exposure to morphine or a combination of cocaine and morphine significantly increases mu receptor density. By P14, mu-opioid receptor binding was no longer different than the control. This may suggest that the effect on receptor may be short-lived and that other key intracellular events may be activated to mediate the long-term effects. Also, the data show that dopaminergic mechanisms are (or opioid-dopamine interaction is) involved in the effects of morphine alone or morphine in combination with cocaine on mu receptor regulation.
机译：我们研究了产前可卡因和吗啡分别或联合给予对（1）产后大脑μ阿片受体发育和（2）多巴胺与μ受体相互作用的影响。从妊娠的第13天到第20天，怀孕的大鼠每天一次腹膜内（I.P.）注射盐水，可卡因（20 mg / kg），吗啡（2 mg / kg）或两种药物的组合。在产后（P）1、7、14和28天，分析了全脑的阿片受体结合和mu mRNA。与对照组相比，在研究的所有天中，单独服用产前可卡因对脑mu受体的个体发育均无明显影响。吗啡治疗组的mu受体与P1和P7的结合显着增加。暴露于可卡因和吗啡均显示P1和P7上的mu受体密度显着增加。此外，在吗啡单独组和联合组中，MOR mRNA也均显着增加。在给药前用多巴胺D2受体拮抗剂（舒必利，20 mg / kg）进行预处理显示，μ受体在P1和P7上的结合减少。这些结果表明，产前暴露于吗啡或可卡因和吗啡的组合会显着增加mu受体密度。通过P14，μ阿片受体的结合不再与对照不同。这可能表明对受体的作用可能是短暂的，并且可能激活其他关键的细胞内事件来介导长期作用。而且，数据显示多巴胺能机制（或阿片-多巴胺相互作用）参与吗啡单独或吗啡联合可卡因对mu受体调节的作用。

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