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首页> 外文期刊>Life sciences >Chronic alcohol consumption, type 2 diabetes mellitus, insulin-like growth factor-I (IGF-I), and growth hormone (GH) in ethanol-treated diabetic rats
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Chronic alcohol consumption, type 2 diabetes mellitus, insulin-like growth factor-I (IGF-I), and growth hormone (GH) in ethanol-treated diabetic rats

机译：乙醇治疗的糖尿病大鼠的慢性酒精消耗，2型糖尿病，胰岛素样生长因子-I（IGF-I）和生长激素（GH）

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Aims: Alcohol has deleterious influences on glucose metabolism which may contribute to the development of type 2 diabetes mellitus (T2DM). Insulin-like growth factor I (IGF-I) and growth hormone (GH), which interact with insulin to modulate metabolic control, have been shown to be related to impaired glucose tolerance. This study was conducted to assess the possibility that altered circulating IGF-I and GH levels contribute to the exacerbation of T2DM by alcohol use in type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats and non-diabetic Long-Evans Tokushima Otsuka (LETO) rats. Main method: OLETF rats were pair-fed a Lieber-DeCarli Regular Ethanol diet and LETO rats were pair-fed a control diet for 6 weeks. At 6 weeks, an Intraperitoneal Glucose Tolerance Test (IP-GTT) was performed and IGF-I and GH levels were evaluated. Key findings: Prior to an IP-GTT, OLETF-Ethanol (O-E) group had significantly a decrease in the mean glucose levels compared to OLETF-Control (O-C) group. At 120 min post IP-GTT, the O-E group had significantly an increase in the mean glucose levels compared to O-C group. The serum IGF-I levels were significantly lower and the serum GH levels were significantly higher in the O-E group than in L-C group. Significance: These results suggest that IGF-I and GH are prominent in defining the risk and development of T2DM, and may be adversely affected by heavy alcohol use, possibly mediating its diabetogenic effects. Thus, the overall glucose intolerance in the setting of alcoholism may be attributable to inappropriate alteration of IGF-I and GH levels.
机译：目的：酒精对葡萄糖代谢有有害影响，可能会导致2型糖尿病（T2DM）的发展。与胰岛素相互作用以调节代谢控制的胰岛素样生长因子I（IGF-1）和生长激素（GH）已被证明与糖耐量降低有关。进行这项研究的目的是评估2型糖尿病大冢长埃文斯德岛胖子（OLETF）大鼠和非糖尿病长谷德长岛大冢（IGETF）大鼠中循环使用的IGF-I和GH水平改变是否会加剧T2DM。 LETO）大鼠。主要方法：OLETF大鼠与Lieber-DeCarli常规乙醇饮食配对喂养，LETO大鼠与对照饮食配对喂养6周。在第6周，进行腹膜内葡萄糖耐量测试（IP-GTT），并评估IGF-I和GH水平。主要发现：在IP-GTT之前，OLETF-乙醇（O-E）组的平均血糖水平明显低于OLETF-Control（O-C）组。 IP-GTT后120分钟，与O-C组相比，O-E组的平均血糖水平显着增加。与L-C组相比，O-E组的血清IGF-I水平显着降低，而GH水平显着升高。意义：这些结果表明，IGF-I和GH在确定T2DM的风险和发展方面很突出，可能因大量饮酒而受到不利影响，可能介导其致糖尿病作用。因此，酒精中毒引起的总的葡萄糖不耐症可能归因于IGF-1和GH水平的不适当改变。

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