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首页> 外文期刊>Life sciences >SYNERGISTIC ABLATION DOES NOT AFFECT ATROPHY OR ALTERED MYOSIN HEAVY CHAIN EXPRESSION IN THE NON-WEIGHT BEARING SOLEUS MUSCLE
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SYNERGISTIC ABLATION DOES NOT AFFECT ATROPHY OR ALTERED MYOSIN HEAVY CHAIN EXPRESSION IN THE NON-WEIGHT BEARING SOLEUS MUSCLE

机译：协同消融不会影响非负重单纯性肌肉中的萎缩或肌球蛋白重链表达的改变

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The purpose of this study was to investigate whether the soleus muscle undergoes atrophy and alterations in myosin heavy chain (MHC) composition during non-weight bearing in the absence of synergists. Thirty-two female rats were randomly assigned to four groups: control (C), synergistic ablation (ABL) of the gastrocnemius and plantaris muscles to overload the soleus muscle, hindlimb suspension (HLS), or a combination of synergistic ablation and hindlimb suspension (HLS-ABL). After 28 days of hindlimb suspension, soleus atrophy was more pronounced in HLS (58%) than in HLS-ABL (43%) rats. Compared to C rats, non-weight bearing decreased mixed and myofibrillar protein contents and Type I MHC 49%, 45%, and 7%, respectively, in HLS animals. In addition, de novo expression of fast Type IIx and Type IIb MHC (5% and 2%, respectively) was observed in HLS animals. Similarly, when compared to C rats, mixed and myofibrillar protein contents and Type I MHC decreased 43%, 46%, and 4%, respectively, in HLS-ABL animals. Also, de novo expression of Type IIx (4%) and IIb (1%) MHC was observed. Collectively, these data indicate that the loss of muscle protein and Type I MHC, and the de novo expression of Type IIx and Type IIb MHC in the rat soleus occur independently of the presence of synergists during non-weight bearing. Furthermore, these results confirm the contention that soleus mass and MHC expression are highly sensitive to alterations in mechanical load. [References: 27]
机译：这项研究的目的是调查在不存在增效剂的情况下非负重期间比目鱼肌是否发生萎缩和肌球蛋白重链（MHC）组成变化。将32只雌性大鼠随机分为四组：对照组（C），腓肠肌和plant肌的协同消融（ABL）使比目鱼肌超负荷，后肢悬吊（HLS）或协同消融与后肢悬吊的组合（ HLS-ABL）。后肢悬吊28天后，比HLS-ABL（43％）大鼠的比目鱼肌萎缩更为明显（58％）。与C大鼠相比，非负重动物在HLS动物中混合和肌原纤维蛋白含量和I型MHC含量分别降低了49％，45％和7％。另外，在HLS动物中观察到快速IIx型和IIb MHC型（分别为5％和2％）的从头表达。同样，与C大鼠相比，HLS-ABL动物的混合和肌原纤维蛋白含量和I型MHC分别降低了43％，46％和4％。另外，观察到IIx（4％）和IIb（1％）MHC的从头表达。总体而言，这些数据表明大鼠比目鱼肌中肌肉蛋白和I型MHC的丢失以及IIx型和IIb MHC型的从头表达与非增重过程中协同剂的存在无关。此外，这些结果证实了比目鱼质量和MHC表达对机械负荷的变化高度敏感的争论。 [参考：27]

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