The Hsp90-specific inhibitor, geldanamycin, blocks CD28-mediated activation of human T lymphocytes.

Schnaider T; Somogyi J; Csermely P; Szamel M

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The Hsp90-specific inhibitor, geldanamycin, blocks CD28-mediated activation of human T lymphocytes.

机译：Hsp90特异性抑制剂格尔德霉素可阻止CD28介导的人类T淋巴细胞活化。

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The 90 kDa heat shock protein (Hsp90) is a molecular chaperone aiding the folding of nuclear hormone receptors and protein kinases. Hsp90-mediated folding can be disrupted by the Hsp90-specific drug, geldanamycin. Here we provide evidence for the inhibition of the CD28-specific BW 828 antibody-mediated activation of human T lymphocyte proliferation, IL-2 secretion and IL-2 receptor expression by geldanamycin. Our results suggest that the major cytoplasmic chaperone, Hsp90, plays an important role in CD28-mediated T lymphocyte activation.

机译：90 kDa热休克蛋白（Hsp90）是一种分子伴侣，可帮助折叠核激素受体和蛋白激酶。 Hsp90特异性药物格尔德霉素可破坏Hsp90介导的折叠。在这里，我们为格尔德霉素抑制CD28特异性BW 828抗体介导的人类T淋巴细胞增殖，IL-2分泌和IL-2受体表达的活化提供了证据。我们的结果表明，主要的细胞质伴侣Hsp90在CD28介导的T淋巴细胞活化中起重要作用。

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《Life sciences》 |1998年第11期|共6页
作者
Schnaider T; Somogyi J; Csermely P; Szamel M;
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正文语种 eng
中图分类生命的起源;生命科学总论;
关键词
Antigens; CD28; Enzyme Inhibitors; Heat-Shock Proteins 90; Quinones; T-Lymphocytes; 抗原; CD28; 酶抑制剂; 热休克蛋白质类90; 醌类; T淋巴细胞;

机译：Antigens;CD28;Enzyme Inhibitors;Heat-Shock Proteins 90;Quinones;T-Lymphocytes;抗原;CD28;酶抑制剂;热休克蛋白质类90;醌类;T淋巴细胞;

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1. The Hsp90-specific inhibitor, geldanamycin, blocks CD28-mediated activation of human T lymphocytes. [J] . Schnaider T, Somogyi J, Csermely P, Life sciences . 1998,第11期

机译：Hsp90特异性抑制剂格尔德霉素可阻止CD28介导的人类T淋巴细胞活化。
2. Nitric oxide-releasing compounds inhibit the production of interleukin-2, -4 and -10 in activated human lymphocytes. [J] . Korhonen R, Kosonen O, Hamalainen M, Basic & clinical pharmacology & toxicology. . 2008,第4期

机译：一氧化氮释放化合物抑制活化的人淋巴细胞中白介素-2，-4和-10的产生。
3. Extracellular Adenine Nucleotides Inhibit the Activation of Human CD4(+) T Lymphocytes. [J] . Duhant X, Schandene L, Bruyns C, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2002,第1期

机译：细胞外腺嘌呤核苷酸抑制人类CD4（+）T淋巴细胞的激活。
4. KG-135 Inhibits COX-2 Expression by Blocking the Activation of JNK and AP-1 in Phorbol Ester-Stimulated Human Breast Epithelial Cells [C] . SIN-AYE PARK, EUN-HEE KIM, HYE-KYUNG NA, Meeting on Cell Signaling World: Signal Transduction Pathways as Therapeutic Targets . 2007

机译：KG-135通过阻断由佛波酯刺激的人乳腺癌上皮细胞中的JNK和AP-1的活化来抑制COX-2的表达
5. Design, synthesis, and evaluation of novel sodium channel blockers as inhibitors of human prostate cancer. [D] . Anderson, James David. 2004

机译：设计，合成和评估新型钠通道阻滞剂作为人类前列腺癌的抑制剂。
6. The Hsp90-specific inhibitor geldanamycin selectively disrupts kinase-mediated signaling events of T-lymphocyte activation [O] . Tamás Schnaider, János Somogyi, Péter Csermely, 2000

机译：Hsp90特异性抑制剂格尔德霉素选择性破坏激酶介导的T淋巴细胞活化的信号事件
7. Blockade of Kv1.3 potassium channels inhibits differentiation and granzyme B secretion of human CD8+ T effector memory lymphocytes. [O] . Lina Hu, Tongguang Wang, Anne R Gocke, 2013

机译：阻断Kv1.3钾通道抑制人CD8 + T效应记忆淋巴细胞的分化和颗粒酶B分泌。

The Hsp90-specific inhibitor, geldanamycin, blocks CD28-mediated activation of human T lymphocytes.

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