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首页> 外文期刊>Life sciences >Development of an experimental ovarian tumor over a year in the rat.
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Development of an experimental ovarian tumor over a year in the rat.

机译：在大鼠中超过一年的实验性卵巢肿瘤的发展。

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Tumor growth, possible malignant transformation or metastatic propagation and hormonal patterns were evaluated over a year in luteoma induced by introducing an ovary into the spleen of ovariectomized 60 day-old rats. Sham castrated animals had a piece of muscle inserted into the spleen. Jugular blood samples were taken monthly. After a year animals were cycled and decapitated. Troncal blood was collected, autopsies were performed and luteoma were measured and fixed in 10% buffered formalin. Serum LH, FSH, PRL, estradiol and progesterone were measured. Serum inhibin content was determined in one month-old tumors-bearing animals and estrous rats as controls. After one year no external changes in tumor-bearing rats were observed, nor differences in body weight or mortality rates compared to Sham animals. Metastatic propagation was absent. Routine histological examination showed two types of tumors according to either granulosa or luteal cell predomination, tumor type did not determine hormonal patterns. However, a clear relationship between gonadotropin levels and tumor size was established. Low gonadotropins: Small tumors, 18.7% of cases and high gonadotropins: Large tumors, 81.3%. In Sham animals gonadotropins attained castrate levels and remained elevated until the end of the experiment. In the Small group no increases in gonadotropins or estradiol were detected, progesterone and PRL fluctuated. In the Large tumor group LH increased to Sham titers until month 7, then fell to initial levels, FSH augmented significantly as from month three and remained high up to month 5. No variations in either estradiol, progesterone or PRL were observed. Serum inhibin of one month-old tumor-bearing rats was significantly elevated, justifying the lack of FSH increase at this time point. We conclude that these luteoma do not suffer malignant transformation or induce metastases. They appear in two histological types. Tumor size depends on hormonal patterns. The delay in the initial increase and the sharp decrease observed in FSH in animals bearing Large tumors suggest a possible role for inhibin in this regulation.
机译：通过在卵巢切除的60日龄大鼠的脾脏中引入卵巢而诱发的黄体瘤，评估了一年多来的肿瘤生长，可能的恶性转化或转移性繁殖以及激素模式。假手术cast割动物的脾脏中插入了一块肌肉。每月抽取颈静脉血样。一年后，将动物循环并斩首。收集创面血，进行尸检，测量黄体瘤并固定在10％福尔马林缓冲液中。测量血清LH，FSH，PRL，雌二醇和孕酮。在一个月大的荷瘤动物和发情大鼠中确定血清抑制素含量。一年后，与假手术动物相比，未观察到荷瘤大鼠的外部变化，体重或死亡率也无差异。没有转移性繁殖。常规组织学检查显示，根据颗粒性或黄体细胞优势，有两种类型的肿瘤，肿瘤类型不能确定激素类型。然而，促性腺激素水平和肿瘤大小之间建立了明确的关系。低促性腺激素：小肿瘤，占18.7％;高促性腺激素：大肿瘤，占81.3％。在深水动物中，促性腺激素达到cast割水平并保持升高，直到实验结束。在小型组中，未检测到促性腺激素或雌二醇增加，孕酮和PRL波动。在大肿瘤组中，LH增加至Sham滴度直至第7个月，然后降至初始水平，FSH从第3个月开始显着增加，直至第5个月仍保持高水平。未观察到雌二醇，孕酮或PRL的变化。一个月大的荷瘤大鼠的血清抑制素显着升高，证明在这个时间点没有FSH升高。我们得出的结论是，这些黄体瘤不会发生恶性转化或诱发转移。它们以两种组织学类型出现。肿瘤大小取决于荷尔蒙模式。在携带大肿瘤的动物中观察到FSH的初始增加延迟和急剧下降，表明抑制素可能在这种调节中起作用。

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