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首页> 外文期刊>Life sciences >Comparison of the effects of serotonin selective, norepinephrine selective, and dual serotonin and norepinephrine reuptake inhibitors on lower urinary tract function in cats.
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Comparison of the effects of serotonin selective, norepinephrine selective, and dual serotonin and norepinephrine reuptake inhibitors on lower urinary tract function in cats.

机译：比较5-羟色胺选择性，去甲肾上腺素选择性以及双重5-羟色胺和去甲肾上腺素再摄取抑制剂对猫下尿路功能的影响。

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摘要

Previous studies showed that the dual serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE) reuptake inhibitor, duloxetine, increases bladder capacity and urethral sphincter electromyographic (EMG) activity in a cat model of acetic acid-induced bladder irritation. The present study aimed to determine the relative importance of 5-HT versus NE reuptake inhibition for mediating these effects by examining drugs that are selective for either the 5-HT or NE system or both. Similar to duloxetine, venlafaxine (0.1 to 10 mg/kg), also a dual serotonin and norepinephrine reuptake inhibitor, produced marked increases in bladder capacity and EMG activity that were reversed by methiothepin (0.3 mg/kg). S-norfluoxetine (0.01 to 10 mg/kg), a serotonin selective reuptake inhibitor, produced small but significant increases in bladder capacity and EMG activity at doses of 3 and 10 mg/kg. Thionisoxetine (0.01 to 3.0 mg/kg), a NE selective reuptake inhibitor, produced no effects on bladder capacity or sphincter EMG activity. Surprisingly, co-administration of thionisoxetine and s-norfluoxetine up to doses of 1 mg/kg of each compound produced no effect on lower urinary tract function. These doses were the maximum that could be administered in combination due to drug-induced emergence of skeletal muscle activity in chloralose-anesthetized animals. These results indicate that there are unexplained pharmacological differences between the effects of single compounds that exhibit dual NE and 5-HT reuptake inhibition and a combination of compounds that exhibit selective NE and 5-HT reuptake inhibition on lower urinary tract function.
机译：先前的研究表明，在乙酸诱发的膀胱刺激性猫模型中，双重5-羟色胺（5-羟色胺，5-HT）和去甲肾上腺素（NE）再摄取抑制剂度洛西汀可增加膀胱容量和尿道括约肌肌电图（EMG）活性。本研究旨在通过检查对5-HT或NE系统或两者均具有选择性的药物，确定5-HT与NE再摄取抑制对介导这些作用的相对重要性。与度洛西汀相似，文拉法辛（0.1至10 mg / kg）也是5-羟色胺和去甲肾上腺素再摄取抑制剂，使膀胱容量和EMG活性显着增加，而甲硫基托平（0.3 mg / kg）逆转了这种作用。 S-去甲氟西汀（0.01至10 mg / kg）是5-羟色胺选择性再摄取抑制剂，在3和10 mg / kg的剂量下，膀胱容量和EMG活性略有增加，但显着增加。硫代异西汀（0.01至3.0 mg / kg）是一种NE选择性再摄取抑制剂，对膀胱容量或括约肌EMG活性没有影响。令人惊讶地，直至每种化合物的1mg / kg的剂量共同施用硫代尼西汀和s-去氟西汀对下尿道功能没有影响。这些剂量是由于氯醛糖麻醉的动物的药物诱导的骨骼肌活性的出现而可以联合施用的最大剂量。这些结果表明，表现出双重NE和5-HT再摄取抑制的单一化合物的作用与表现出选择性NE和5-HT再摄取抑制的化合物的组合对下尿路功能的作用之间存在无法解释的药理学差异。

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