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首页> 外文期刊>Life sciences >Excitatory action of lead on rat sympathetic preganglionic neurons in vitro and in vivo.
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Excitatory action of lead on rat sympathetic preganglionic neurons in vitro and in vivo.

机译：铅在体外和体内对大鼠交感神经节前神经元的兴奋作用。

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Lead exposure elicited an increase in blood pressure and was considered to be a cardiovascular risk factor. The involvements of sympathetic nervous system and circulating catecholamines have been implicated in lead-induced hypertension. This study examined the effects of PbCl(2) on sympathetic preganglionic neurons (SPNs) in vitro and in vivo. In vitro electrophysiological study showed that superfusion of a low concentration (5 microM) of PbCl(2), which had no effects on membrane potential and spontaneous discharge rate, enhanced excitatory postsynaptic potentials (EPSPs) in some of the SPNs examined but inhibited inhibitory postsynaptic potentials (IPSPs) in other SPNs tested. A higher concentration (50 microM) of PbCl(2) inhibited both EPSPs and IPSPs in all SPNs examined. In vivo study showed that intrathecal injection of PbCl(2) (10 and 100 nmol) via an implanted cannula to the T7-T9 segments of urethane-anesthetized rats increased both the heart rate and mean arterial pressure. The pressor and tachycardic responses of intrathecal PbCl(2) (100 nmol) were attenuated by pretreatment with intravenous administration of hexamethonium (10 mg/kg) or intrathecal AP-5 (DL-2-amino-5-phosphonovaleric acid, 100 nmol), but were not significantly antagonized by prior intrathecal administration of CNQX (6-cyano-7-nitroquinoxaline-2,3-dione, 100 nmol). Taken together, these results demonstrated that lead may exert a stimulatory effect on SPNs, which may result from the enhancement of EPSPs and inhibition of IPSPs by low concentrations of lead.
机译：铅暴露引起血压升高，被认为是心血管危险因素。交感神经系统和循环儿茶酚胺的参与已牵涉铅诱发的高血压。这项研究检查了PbCl（2）在体外和体内对交感神经节前神经元（SPNs）的影响。体外电生理研究表明，低浓度（5 microM）的PbCl（2）的融合对膜电位和自发放电率没有影响，在某些受检的SPN中增强了兴奋性突触后电位（EPSP），但抑制了抑制性突触后突触。其他SPN中的电势（IPSP）。更高的浓度（50 microM）的PbCl（2）抑制了所有检查的SPN中的EPSP和IPSP。体内研究表明鞘内注射PbCl（2）（10和100 nmol）通过植入的插管到氨基甲酸乙酯麻醉大鼠的T7-T9节段可增加心率和平均动脉压。鞘内注射PbCl（2）（100 nmol）的加压和心动过速反应通过静脉内施用六甲铵（10 mg / kg）或鞘内注射AP-5（DL-2-氨基-5-膦酰戊酸，100 nmol）来减轻，但在事先鞘内注射CNQX（6-氰基-7-硝基喹喔啉-2,3-二酮，100 nmol）时并未明显拮抗。综上所述，这些结果表明铅可能对SPN产生刺激作用，这可能是由于低浓度铅导致EPSP增强和IPSP抑制所致。

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