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Antioxidant activity of anti-inflammatory plant extracts.

机译：抗炎植物提取物的抗氧化活性。

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摘要

The antioxidant properties of twenty medical herbs used in the traditional Mediterranean and Chinese medicine were studied. Extracts from Forsythia suspensa, Helichrysum italicum, Scrophularia auriculata, Inula viscosa, Coptis chinensis, Poria cocos and Scutellaria baicalensis had previously shown anti-inflammatory activity in different experimental models. Using free radical-generating systems H. italicum. I. viscosa and F. suspensa protected against enzymatic and non-enzymatic lipid peroxidation in model membranes and also showed scavenging property on the superoxide radical. All extracts were assayed at a concentration of 100 microg/ml. Most of the extracts were weak scavengers of the hydroxyl radical and C. chinensis and P. cocos exhibited the highest scavenging activity. Although S. baicalensis inhibited the lipid peroxidation in rat liver microsomes and red blood cells, the extract showed inhibitory actions on aminopyrine N-demethylase and xanthine oxidase activities as well as an pro-oxidant effect observed in the Fe3+-EDTA-H2O2 system. The results of the present work suggest that the anti-inflammatory activities of the same extracts could be explained, at least in part, by their antioxidant properties.
机译：研究了20种传统地中海和中药材的抗氧化性能。连翘，蜡菊，玄参，旋覆花，黄连，ia和黄S的提取物以前在不同的实验模型中显示出抗炎活性。使用自由基产生系统H. italicum。 I.粘胶和F.suspensa可以防止模型膜中的酶和非酶脂质过氧化作用，并且对超氧化物自由基也具有清除作用。所有提取物的浓度均为100微克/毫升。大部分提取物是弱的羟基自由基清除剂，中华隐球菌和椰子均具有最高的清除活性。尽管黄ical抑制了大鼠肝微粒体和红细胞中的脂质过氧化，但提取物显示出对氨基比林N-脱甲基酶和黄嘌呤氧化酶活性的抑制作用以及在Fe3 + -EDTA-H2O2系统中观察到的促氧化作用。本工作的结果表明，相同提取物的抗炎活性至少可以通过其抗氧化特性来解释。

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