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首页> 外文期刊>Life sciences >Immunological responses to ultraviolet light B radiation in Black individuals.
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Immunological responses to ultraviolet light B radiation in Black individuals.

机译：黑人个体对紫外线B辐射的免疫反应。

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摘要

Immunological factors are important participants in the pathogenesis of experimental skin tumors. We therefore studied cutaneous immune responses in subjects with either low natural incidence (Black individuals), or a high frequency rate (White individuals) of skin cancer. We performed whole body irradiation with a low dose of ultraviolet light B (UV-B) and evaluated peripheral lymphocytes. UV-B irradiation was associated with small but significant changes in lymphocyte phenotype frequency. In White subjects this consisted of an increased number of CD19 (B cells) and CD 4/29 (inducer of helper T cells); Black subjects had a slight decrease in CD3 (T cells). Natural killer activity, not affected by UV-B in White subjects, increased significantly in Black subjects. UV-B was devoid of immunological effects in vitro for any of the parameters tested. As expected, the low UV-B dose used in this study induced increases of serum vitamin D3 concentrations in White subjects, with lack of response in the Black subjects. We conclude that Black individuals selectively exhibit an increase in Natural Killer activity in response to irradiation with low dose UV-B. This race group-specific immune response to ultraviolet radiation appears to require mediation by the skin. Enhanced Natural Killer activity could underlie at least partly the resistance in Black individuals to the development of photodependent skin cancer.
机译：免疫学因素是实验性皮肤肿瘤发病机理的重要参与者。因此，我们在皮肤癌的自然发病率低（黑人）或高频率（白人）的受试者中研究了皮肤免疫反应。我们用低剂量的紫外线B（UV-B）进行了全身照射，并评估了外周淋巴细胞。 UV-B照射与淋巴细胞表型频率的微小但显着变化有关。在白人受试者中，这由增加数量的CD19（B细胞）和CD 4/29（辅助T细胞的诱导剂）组成。黑人受试者的CD3（T细胞）略有下降。在白人受试者中不受紫外线-B影响的自然杀手活性在黑人受试者中显着增加。对于任何测试参数，UV-B在体外均无免疫学作用。不出所料，本研究中使用的低UV-B剂量导致白人受试者血清维生素D3浓度增加，而黑人受试者则缺乏反应。我们得出的结论是，黑人对低剂量的UV-B辐射有选择性地表现出自然杀伤活性的提高。这种对紫外线辐射的种族特异性免疫反应似乎需要由皮肤介导。增强的自然杀手活性可能至少部分是黑人个体对光依赖性皮肤癌发展的抵抗力。

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