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首页> 外文期刊>Life sciences >Effects of melatonin, morphine and diazepam on formalin-induced nociception in mice.
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Effects of melatonin, morphine and diazepam on formalin-induced nociception in mice.

机译：褪黑素，吗啡和地西epa对福尔马林诱导的小鼠伤害感受的影响。

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摘要

The possible analgesic effect of melatonin was investigated in young male ICR mice. The formalin test which elicits typically 2 phases of pain response, the acute (first) phase and tonic (second) phase, was used. The test was performed in the late light period when the mice have been reported to be more sensitive to pain. Compared to control mice, no significant difference in nociceptive response was observed when melatonin was injected intraperitoneally at doses of 0.1, 5, and 20, mg/kg body weight. The combined effects of melatonin with diazepam and/or morphine, were also investigated. Melatonin, injected at 20 mg/kg 15 min before formalin test, significantly increased the antinociceptive response of diazepam (1 mg/kg) or morphine (5 mg/kg) in the second phase. In addition, when melatonin was given at 20 mg/kg together with diazepam and morphine, antinociceptive responses in both the first and second phase were increased. These data indicate the synergistic analgesia effect of melatonin with morphine and diazepam and suggest the possible involvement of melatonin as an adjunct medicine for pain patients.
机译：在年轻的雄性ICR小鼠中研究了褪黑激素的可能的镇痛作用。使用福尔马林测试，通常会引起两个阶段的疼痛反应，即急性（第一阶段）和进补（第二阶段）。据报道，小鼠对疼痛更敏感，是在晚期光照下进行的。与对照小鼠相比，当以0.1、5和20 mg / kg体重腹膜内注射褪黑激素时，在伤害感受方面没有观察到显着差异。还研究了褪黑激素与地西epa和/或吗啡的联合作用。在福尔马林测试前15分钟以20 mg / kg注射褪黑激素，可在第二阶段显着提高地西epa（1 mg / kg）或吗啡（5 mg / kg）的抗伤害感受性。此外，当褪黑激素与地西epa和吗啡一起以20 mg / kg的剂量给药时，第一阶段和第二阶段的抗伤害感受反应都会增加。这些数据表明褪黑激素与吗啡和地西epa的协同镇痛作用，并提示褪黑激素可能作为疼痛患者的辅助药物。

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