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首页> 外文期刊>Life sciences >The herbal medicine Dai-kenchu-to and one of its active components [6]-shogaol increase intestinal blood flow in rats
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The herbal medicine Dai-kenchu-to and one of its active components [6]-shogaol increase intestinal blood flow in rats

机译：草药大kenchu-to及其有效成分之一[6] -shogaol可增加大鼠肠血流量

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The present study investigated the effects of the herbal medicine Dai-kenchu-to (DKCT) and its 4 individual ingredients on intestinal blood flow (IBF) in rats by laser Doppler flowmetry. Intraduodenal administration of DKCT (30, 100 and 300 mg/kg) increased IBF in a dose-dependent manner, whereas the mean arterial blood pressure was not affected. One of the ingredients in DKCT is dried ginger rhizome (150 mg/kg), whose main component is [6]-shogaol (2 mg/kg), both of which showed similar in effects to those shown by DKCT, while the other ingredients in DKCT only slightly creased IBF or had no effect. The calcitonin gene-related peptide (CGRP) receptor antagonist, CGRP (8-37), completely abolished the hyperemia induced by DKCT, dried ginger rhizome and [6]-shogaol. However, the vasoactive intestinal polypeptide (VIP) receptor antagonist, [4-0-DPhe6, Leu17]-VIP, and atropine were less inhibitory than CGRP (8-37), and the substance P (SP) receptor antagonist, spantide, had no effect. The present study demonstrated that DKCT and one of its active components, [6]-shogaol, produced an increase in IBF which was mainly mediated by CGRP and suggests that DKCT may be useful in the treatment of intestinal ischemia-related diseases. (C) 2002 Elsevier Science Inc. All rights reserved. [References: 25]
机译：本研究通过激光多普勒血流仪研究了大鼠大肠中药（DKCT）及其4种单独成分对肠道血流（IBF）的影响。十二指肠内施用DKCT（30、100和300 mg / kg）以剂量依赖性方式增加IBF，而平均动脉血压不受影响。 DKCT中的成分之一是干姜根茎（150 mg / kg），其主要成分是[6]-松果酚（2 mg / kg），两者的功效均与DKCT所示的相似，而其他成分在DKCT中，IBF仅略微增加或没有作用。降钙素基因相关肽（CGRP）受体拮抗剂CGRP（8-37）完全消除了DKCT，干姜根茎和[6] -shogaol引起的充血。但是，血管活性肠多肽（VIP）受体拮抗剂[4-0-DPhe6，Leu17] -VIP和阿托品的抑制作用不如CGRP（8-37），而P（SP）物质受体拮抗剂spantide具有没有效果。本研究表明，DKCT及其活性成分之一[6] -shogaol导致IBF的增加，而IBF的增加主要是由CGRP介导的，提示DKCT可能在治疗与肠缺血相关的疾病中有用。 （C）2002 Elsevier Science Inc.保留所有权利。 [参考：25]

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