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首页> 外文期刊>Life sciences >DIFFERENT NEUROTRANSMITTER SYSTEMS ARE INVOLVED IN THE DEVELOPMENT OF ESOPHAGEAL ACHALASIA
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DIFFERENT NEUROTRANSMITTER SYSTEMS ARE INVOLVED IN THE DEVELOPMENT OF ESOPHAGEAL ACHALASIA

机译：食管黏膜症的发展涉及不同的神经发射系统

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摘要

Clinical and pharmacological evidence suggests that several neurotransmitters are involved in the control of the esophageal motilility; in fact, besides the well known cholinergic and sympathetic innervation, Vasoactive Intestinal Polypeptide (VIP)-containing fibers as well as dopamine (DA)-containing nerve endings have been identified within the esophageal wall. Lower Esophageal Sphincter (LES) achalasia is a neuromuscular disorder characterized by the absence of peristalsis in the body of the esophagus and by the failure of the LES to relax in response to swallowing. Stimulation of both VIP receptors and D-2 DA receptors induce a decrease in LES pressure, while D-l receptors mediate LES contractions. In the present study we show that both VIP and DA system is disregulated in LES achalasia. In particular, this disease is associated not only with the lack of VIP nerves in the LES, but also with a failure in the responsiveness of postsynaptic receptors to VIP stimulation. Furthermore, we demonstrate a selective functional loss of the D-2 DA receptor component, without changes in the D-l DA receptor mediated responses. [References: 27]
机译：临床和药理学证据表明，几种神经递质参与了食管运动的控制。实际上，除了众所周知的胆碱能和交感神经支配，在食管壁中还发现了含有血管活性肠多肽（VIP）的纤维以及含有多巴胺（DA）的神经末梢。食管下括约肌（LES）al门失弛缓症是一种神经肌肉疾病，其特征是食管体内没有蠕动，并且LES无法响应吞咽而放松。 VIP受体和D-2DA受体的刺激均导致LES压力降低，而D-1受体介导LES收缩。在本研究中，我们表明，LES achalasia中的VIP和DA系统均失调。特别地，该疾病不仅与LES中缺乏VIP神经有关，而且与突触后受体对VIP刺激的反应性失败有关。此外，我们证明了D-2 DA受体组分的选择性功能丧失，而D-1 DA受体介导的反应没有改变。 [参考：27]

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